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1. (WO2010085449) VESSEL PUNCTURE CLOSURE DEVICE
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CLAIMS

1. A vessel puncture closure device for sealing a vessel puncture in a patient comprising: a unitary T-shaped puncture sealant comprising a planar base hingedly connected to a planar post prior to delivery in the patient, the planar post comprising at least one puncture tract retainment member, the base comprising two legs projecting in opposite directions from a proximal end of the post, the puncture sealant being formed from a planar elongate sheet of foldably bonded biocompatible material; and a suture attachably extending from the post, wherein the base is configured to seal the vessel puncture, while allowing fluid flow through a blood vessel following deployment; and wherein the puncture tract retainment member is configured to prevent reentry of the post into a blood vessel lumen and facilitate the seating of the base against the inside wall of the vessel following deployment.

2. The device of claim 1 , wherein each of the base and post comprises a planar elongate structure having a rectangular or obround shape.

3. The device of claim 1 , wherein the length of the post exceeds the length of at least one leg.

4. The device of claim 1 , wherein the puncture tract retainment member comprises a first barb extending substantially perpendicularly from a first plane face of the post when deployed in a patient, and a second barb extending substantially perpendicularly from a second plane face of the post when deployed in a patient, each of the first and second barbs comprising two edges joined to form a pointed end extending downward toward the outer surface of the vessel upon deployment over the puncture, wherein the pointed ends in the first and second barbs extend from opposite sides of the post when deployed.

5. The device of claim 4, wherein each of the first and second barbs foldably extends from an edge of the post.

6. The device of claim 1 , wherein the sheet of foldably bonded biocompatible material comprises a synthetic polymeric sheet material.

7. The device of claim 1 , wherein the sheet of foldably bonded biocompatible material comprises an ECM sheet material.

8. The device of claim 1 , comprising a sheet of foldably bonded biocompatible material, the sheet defined by terminal sheet portions flanking a central sheet portion, wherein the terminal sheet portions are foldably bonded to one another to form the post, and central sheet portions are foldably bonded to one another to form the two legs.

9. The device of claim 1 , comprising a sheet of foldably bonded biocompatible material, the sheet defined by terminal sheet portions flanking a central sheet portion, wherein a proximal portion of the central sheet is foldably bonded to a distal portion of the central sheet portion to form the post.

10. The device of claim 1 , wherein the puncture tract retainment member comprises a first barb extending substantially perpendicular from a first plane face of the post when deployed in a patient, and a second barb extending substantially perpendicular from a second plane face of the post when deployed in a patient, each of the first and second barbs comprises two edges joined to form a pointed end extending downward toward the outer surface of the vessel upon deployment over the puncture, wherein the pointed ends in the first and second barbs extend from opposite sides the post when deployed.

11. The device of claim 10, wherein each of the first and second barbs foldably extends from an edge of the post.

12. The device of claim 1 , wherein the sheet of foldably bonded biocompatible material comprises ECM sheet material.

13. The device of claim 12, wherein the ECM sheet material comprises a plurality of laminated ECM tissue layers.

14. The device of claim 12, wherein the ECM sheet material further comprises a stiffening material increasing the rigidity of the ECM sheet material.

15. The device of claim 14, wherein the base comprises the stiffening material.

16. The device of claim 14, wherein the stiffening material comprises a chemical crosslinker, a wire, a polymeric substance, an adhesive, or combination thereof.

17. The device of claim 14, wherein the stiffening material comprises a polymeric substance.

18. The device of claim 17, wherein the polymeric substance is applied as a coating onto one or more surfaces of the ECM sheet material.

19. The device of claims 17, wherein the polymeric substance comprises a poly(ethylene glycol) polymer.

20. The device of claim 17, wherein the polymeric substance or adhesive is incorporated between one or more sheets of ECM material or between one or more ECM tissue layers in any one of the one or more sheets ECM material.

21. A device assembly comprising: the device of claim 1 ; and a deployment shaft comprising a lumen, a sheath, a distal shaft end, and a proximal shaft end; wherein the device is connectively linked to the deployment shaft by the bioabsorbable suture, the bioabsorbable suture extending through the deployment shaft lumen from the distal shaft end past the proximal shaft end

22. The device assembly of claim 21 , further comprising: a transfer tube comprising a transfer tube lumen and a transfer tube sheath, including a proximal transfer tube end and proximal transfer tube end; wherein the device of claim 1 is coaxially disposed in the transfer tube lumen; and wherein the deployment shaft is configured to coaxially extend through the transfer tube lumen and through an introducer.

23. A method for sealing a percutaneous puncture in a blood vessel of a patient comprising: connectively linking each of the device of claim 1 and a deployment shaft to an introducer; pushing the device by extending the deployment shaft through the introducer in a proximal to distal direction; extending the puncture sealant through the puncture site and an adjoining puncture tract extending into the vessel lumen; retracting the deployment shaft from the introducer sheath; pulling the bioabsorbable suture in a distal to proximal direction to translocate the post and the puncture tract retainment member from the vessel lumen, through the puncture, and into the puncture tract, wherein translocation of the at least one puncture tract retainment member into the puncture tract creates a puncture sealant configuration preventing re-entry of the post and facilitates seating of the base against the inner surface of the vessel wall to seal the puncture, while allowing fluid flow through the vessel.

24. The method of claim 23, wherein the step of connectively linking each of the device of claim 1 and the deployment shaft to the introducer comprises linking a transfer tube preloaded with the device to an introducer through a check flow seal in an adaptor linked to the proximal end of the introducer.