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1. (WO2010085385) METHODS FOR SUPPRESSING TIP DC TRAFFICKING OR ACCUMULATION AND PREVENTING HYPERCYTOKINEMIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/085385 International Application No.: PCT/US2010/020608
Publication Date: 29.07.2010 International Filing Date: 11.01.2010
IPC:
A01N 43/40 (2006.01) ,A61K 31/445 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
34
having rings with one nitrogen atom as the only ring hetero atom
40
six-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
Applicants:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 262 Danny Thomas Place Memphis, TN 38105-2794, US (AllExceptUS)
ALDRIDGE, JR., Jerry, R. [US/US]; US (UsOnly)
MOSELEY, Carson, E. [US/US]; US (UsOnly)
Inventors:
ALDRIDGE, JR., Jerry, R.; US
MOSELEY, Carson, E.; US
Agent:
LICATA, Jane, Massey; Licata & Tyrrell P.C. 66 E. Main Street Marlton, NJ 08053, US
Priority Data:
61/146,10321.01.2009US
Title (EN) METHODS FOR SUPPRESSING TIP DC TRAFFICKING OR ACCUMULATION AND PREVENTING HYPERCYTOKINEMIA
(FR) PROCÉDÉS POUR SUPPRIMER UN TRAFIC OU UNE ACCUMULATION DE CELLULES DENDRITIQUES DE POINTE ET EMPÊCHER UNE HYPERCYTOKINÉMIE
Abstract:
(EN) The present invention features methods for preventing or ameliorating hypercytokinemia or preventing lethality- associated with infection by highly pathogenic strains of influenza virus by suppressing TNF-α/lnducible nitric oxide synthase -Producing dendritic cell trafficking or accumulation. In particular embodiments, the expression or activity of MyD88, CCR2, MCP-I or MCP-3 is targeted.
(FR) La présente invention porte sur des procédés pour empêcher ou pour améliorer l'hypercytokinémie ou pour empêcher la mortalité associée à une infection par des souches hautement pathogènes de virus de la grippe par suppression du trafic ou de l'accumulation de cellules dendritiques produisant de la TNF-α/synthase d'oxyde nitrique inductible. Dans des modes de réalisation particuliers, l'expression ou l'activité de MyD88, de CCR2, de MCP-I ou de MCP-3 est visée.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120022113