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1. (WO2010084481) LAYERED SCAFFOLD SUITABLE FOR OSTEOCHONDRAL REPAIR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/084481 International Application No.: PCT/IE2010/000005
Publication Date: 29.07.2010 International Filing Date: 25.01.2010
IPC:
A61L 27/12 (2006.01) ,A61L 27/24 (2006.01) ,A61L 27/42 (2006.01) ,A61L 27/46 (2006.01) ,A61L 27/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
02
Inorganic materials
12
Phosphorus-containing materials, e.g. apatite
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
24
Collagen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
40
Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
42
having an inorganic matrix
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
40
Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
44
having a macromolecular matrix
46
with phosphorus-containing inorganic fillers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
56
Porous or cellular materials
Applicants:
ROYAL COLLEGE OF SURGEONS IN IRELAND [IE/IE]; 123 St. Stephen's Green Dublin 2, IE (AllExceptUS)
GLEESON, John, P [IE/IE]; IE (UsOnly)
LEVINGSTONE, Tanya, J. [IE/IE]; IE (UsOnly)
O'BRIEN, Fergal, J. [IE/IE]; IE (UsOnly)
Inventors:
GLEESON, John, P; IE
LEVINGSTONE, Tanya, J.; IE
O'BRIEN, Fergal, J.; IE
Agent:
PURDY, Hugh, Barry; PURDYLUCEY Intellectual Property Suites 138 /139 The Capel Building Mary's Abbey Dublin 7, IE
Priority Data:
61/147,00623.01.2009US
EP09151226.923.01.2009EP
Title (EN) LAYERED SCAFFOLD SUITABLE FOR OSTEOCHONDRAL REPAIR
(FR) ÉCHAFAUDAGE STRATIFIÉ ADAPTÉ À LA RÉPARATION OSTÉOCHONDRALE
Abstract:
(EN) The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilising the suspension to provide a first layer; optionally preparing a further suspension of collagen and adding the further suspension onto the layer formed in the previous step to form a further layer, and freezing or lyophilising the layers, wherein when the layer formed in the previous step is formed by lyophilisation the lyophilised layer is re-hydrated prior to addition of the next layer; optionally, repeating the aforementioned step to form one or more further layers; and preparing a final suspension of collagen and pouring the final suspension onto the uppermost layer to form a final layer, and freeze-drying the layers to form the multilayer collagen composite scaffold.
(FR) La présente invention concerne une méthode de production d'un échafaudage de collagène multicouche. Ladite méthode comprend, d'une manière générale, les étapes suivantes : préparation d'une première suspension de collagène et congélation ou lyophilisation de la suspension afin de former une première couche; éventuellement, préparation d'une autre suspension de collagène et ajout de l'autre suspension sur la couche formée lors de l'étape précédente afin de former une autre couche, et congélation ou lyophilisation des couches (lorsque la couche formée durant l'étape précédente est formée par lyophilisation, la couche lyophilisée est réhydratée avant l'ajout de la couche suivante); éventuellement, répétition de l'étape susmentionnée pour former une ou plusieurs autres couches; préparation d'une suspension finale de collagène, distribution de la suspension finale sur la couche supérieure pour former une couche finale, et lyophilisation des couches pour former l'échafaudage composite de collagène multicouche.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2389204US20120015003CA2750605US20140105954US20150257870AU2010207472
US20170157288