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1. (WO2010084402) HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/084402 International Application No.: PCT/IB2010/000094
Publication Date: 29.07.2010 International Filing Date: 21.01.2010
IPC:
C07D 413/04 (2006.01) ,C07D 417/04 (2006.01) ,C07D 417/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
Applicants:
ORCHID RESEARCH LABORATORIES LTD. [IN/IN]; Orchid Towers 313, Valluvar Kottam High Road Nungambakkam 60034 Chennai, Tamilnadu, IN (AllExceptUS)
BALASUBRAMANIAN, Gopalan [IN/IN]; IN (UsOnly)
NARAYANAN, Sukunath [IN/IN]; IN (UsOnly)
SHARMA, Ganapavarapu, vEERA, rAGHAVA [IN/IN]; IN (UsOnly)
ANDIAPPAN, Lavanya [IN/IN]; IN (UsOnly)
NARAYANAN, Shridhar [IN/IN]; IN (UsOnly)
SAXENA, Sanjeev [IN/IN]; IN (UsOnly)
RAJAGOPAL, Sridharan [IN/IN]; IN (UsOnly)
VISHWAKARMA, Lolaknath, Santosh [IN/IN]; IN (UsOnly)
THIRUNAVUKKARASU, Saravanan [IN/IN]; IN (UsOnly)
Inventors:
BALASUBRAMANIAN, Gopalan; IN
NARAYANAN, Sukunath; IN
SHARMA, Ganapavarapu, vEERA, rAGHAVA; IN
ANDIAPPAN, Lavanya; IN
NARAYANAN, Shridhar; IN
SAXENA, Sanjeev; IN
RAJAGOPAL, Sridharan; IN
VISHWAKARMA, Lolaknath, Santosh; IN
THIRUNAVUKKARASU, Saravanan; IN
Agent:
G., Arun, Kumar; K & S Partners B.K. House, Plot No. 109 Sector-44 122002 Gurgaon Haryana, IN
Priority Data:
143/CHE/200922.01.2009IN
Title (EN) HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE PHOSPHODIESTÉRASE
Abstract:
(EN) Described are compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.
(FR) L'invention concerne des composés de formule (I), leurs dérivés, analogues, formes tautomères, régioisomères, stéréoisomères, polymorphes, solvates, intermédiaires, sels pharmaceutiquement acceptables, compositions pharmaceutiques, N-oxydes, métabolites et promédicaments. Ces composés sont des inhibiteurs de phosphodiestérase de type 4 (PDE4). Ils sont utiles pour le traitement de diverses maladies allergiques ou inflammatoires, y compris l'asthme, la BPCO, la bronchite chronique, la dermite atopique, la rhinite allergique, la conjonctivite allergique, la conjonctivite printanière, le psoriasis, la polyarthrite rhumatoïde, la recto-colite hémorragique, la maladie de Crohn, l'uvéite, la NASH et le lupus.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379538US20110269753