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1. (WO2010084197) METHODS FOR PRODUCING MIXTURES OF ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/084197 International Application No.: PCT/EP2010/050822
Publication Date: 29.07.2010 International Filing Date: 26.01.2010
IPC:
C07K 16/00 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/32 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
GENMAB A/S [DK/DK]; P.O. Box 9068 Bredgade 34 DK-1260 Copenhagen K, DK (AllExceptUS)
PARREN, Paul [NL/NL]; NL (UsOnly)
NEIJSSEN, Joost J. [NL/NL]; NL (UsOnly)
LABRIJN, Aran Frank [NL/NL]; NL (UsOnly)
SCHUURMAN, Janine [NL/NL]; NL (UsOnly)
VINK, Tom [NL/NL]; NL (UsOnly)
VAN DE WINKEL, Jan [NL/NL]; NL (UsOnly)
LOVERIX, Stefan [BE/BE]; BE (UsOnly)
LASTERS, Ignace [BE/BE]; BE (UsOnly)
Inventors:
PARREN, Paul; NL
NEIJSSEN, Joost J.; NL
LABRIJN, Aran Frank; NL
SCHUURMAN, Janine; NL
VINK, Tom; NL
VAN DE WINKEL, Jan; NL
LOVERIX, Stefan; BE
LASTERS, Ignace; BE
Priority Data:
PA 2009 0011826.01.2009DK
Title (EN) METHODS FOR PRODUCING MIXTURES OF ANTIBODIES
(FR) PROCÉDÉS POUR PRODUIRE DES MÉLANGES D'ANTICORPS
Abstract:
(EN) The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
(FR) La présente invention concerne un procédé de production d'un mélange comprenant deux ou plusieurs anticorps différents dans une seule cellule hôte recombinante. Dans un mode de réalisation, un mélange de différents anticorps monovalents est produit. Dans un autre mode de réalisation, un mélange d'anticorps monovalents et bivalents est produit. L'invention concerne également des mélanges d'anticorps pouvant être obtenus par le procédé de l'invention et des séquences de chaînes légères qui sont particulièrement utiles dans le procédé de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG172977EP2389392JP2012515540US20120020952CN102365296CN104262483
JP2016165285IN5989/CHENP/2011