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1. (WO2010084157) MULTIFUNCTIONAL STEALTH NANOPARTICLES FOR BIOMEDICAL USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/084157 International Application No.: PCT/EP2010/050693
Publication Date: 29.07.2010 International Filing Date: 21.01.2010
IPC:
A61K 47/48 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3, rue Michel Ange F-75016 Paris, FR (AllExceptUS)
UNIVERSITE DE STRASBOURG [FR/FR]; 4 rue Blaise Pascal F-67000 Strasbourg, FR (AllExceptUS)
INSTITUTE OF MACROMOLECULAR CHEMISTRY AS CR, v. v. i. [CZ/CZ]; Heyrovsky Sq. 2, 162 06 Praha 6, CZ (AllExceptUS)
SCHNEIDER, Grégory F. [FR/FR]; FR (UsOnly)
DECHER, Gero [DE/DE]; DE (UsOnly)
ULBRICH, Karel [CZ/CZ]; CZ (UsOnly)
SUBR, Vladimir [CZ/CZ]; CZ (UsOnly)
Inventors:
SCHNEIDER, Grégory F.; FR
DECHER, Gero; DE
ULBRICH, Karel; CZ
SUBR, Vladimir; CZ
Agent:
WARCOIN, Jacques; Cabinet Regimbeau 20, rue de Chazelles F-75847 Paris Cedex 17, FR
Priority Data:
09305055.721.01.2009EP
Title (EN) MULTIFUNCTIONAL STEALTH NANOPARTICLES FOR BIOMEDICAL USE
(FR) NANOPARTICULES FURTIVES MULTIFONCTIONNELLES POUR USAGE BIOMÉDICAL
Abstract:
(EN) The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
(FR) La présente invention concerne le domaine des nanosystèmes d'administration de médicament. Plus précisément, la présente invention porte sur un copolymère doté de propriétés avantageuses pour le revêtement externe de diverses nanoparticules. Ledit copolymère comprend au moins trois types de monomères présentant des propriétés en termes de furtivité, de couplage et de thérapeutique respectivement, ainsi qu'un quatrième type optionnel de monomères avec des propriétés de ciblage. La présente invention concerne en outre des nanoparticules noyau/coquille ou coquille creuse revêtues d'une couche externe du copolymère selon l'invention. Plusieurs types de nanoparticules noyau/coquille sont considérés. L'invention porte également sur des procédés de préparation desdites nanoparticules, ainsi que sur des compositions pharmaceutiques ou des médicaments les comprenant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2389199US20120082728