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1. (WO2010083633) COMPOUNDS UESED FOR ANTI-HYPERTENSION, PREPARATION METHODS, COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/083633 International Application No.: PCT/CN2009/000602
Publication Date: 29.07.2010 International Filing Date: 27.05.2009
IPC:
C07D 403/10 (2006.01) ,A61K 31/4164 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/12 (2006.01) ,C07D 233/90 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
66
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
90
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants:
王建民 WANG, Jianmin [CN/CN]; CN
Inventors:
王建民 WANG, Jianmin; CN
Agent:
北京泛华伟业知识产权代理有限公司 PANAWELL & PARTNERS, LLC; 中国北京市 朝阳区朝阳门外大街16号中国人寿大厦10层1002-1005 1002-1005, China Life Tower 16 Chao Yang Men Wai Street, Chaoyang District Beijing 100020, CN
Priority Data:
200910076875.923.01.2009CN
Title (EN) COMPOUNDS UESED FOR ANTI-HYPERTENSION, PREPARATION METHODS, COMPOSITIONS AND USES THEREOF
(FR) COMPOSÉS UTILISÉS CONTRE L'HYPERTENSION, LEURS PROCÉDÉS DE PRÉPARATION, LEURS COMPOSITIONS ET LEURS UTILISATIONS
(ZH) 抗高血压化合物及其制备方法、药物组合物和用途
Abstract:
(EN) Compounds used for anti-hypertension, preparation methods, compositions and uses thereof are provided. The compounds used for anti-hypertension are represented by formula (I)as illustrated below, or pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or racemates thereof. Wherein R1, R2, R3 and R4 are each independently: H, alkyl , cycloalkyl, alkylthio , alkoxyl , aryl, arylalkyl, each optionally substituted ,or R1 and R2 together represent cycloalkyl which is optionally substituted, or R2 and R3 together represent heterocyclic radical which is optionally substituted, or R3 and R4 together represent heterocyclic radical which is optionally substituted.
(FR) L'invention porte sur des composés utilisés contre l'hypertension, sur leurs procédés de préparation, sur leurs compositions et sur leurs utilisations. Les composés utilisés contre l'hypertension sont représentés par la formule (I) telle qu'illustrée ci-dessous, ou des sels pharmaceutiquement acceptables, solvates, polymorphes, énantiomères ou racémates de ceux-ci. Dans la formule, R1, R2, R3 et R4 représentent chacun indépendamment : H, alkyle, cycloalkyle, alkylthio, alcoxyle, aryle, arylalkyle, chacun étant éventuellement substitué, ou R1 et R2 représentent ensemble un cycloalkyle qui est éventuellement substitué, ou R2 et R3 représentent ensemble un radical hétérocyclique qui est éventuellement substitué, ou R3 et R4 représentent ensemble un radical hétérocyclique qui est éventuellement substitué.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)