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1. (WO2010083141) BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/083141 International Application No.: PCT/US2010/020710
Publication Date: 22.07.2010 International Filing Date: 12.01.2010
IPC:
C07D 471/04 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 25/28 (2006.01) ,C07D 417/12 (2006.01) ,C07D 513/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543-4000, US (AllExceptUS)
MARCIN, Lawrence, R. [US/US]; US (UsOnly)
THOMPSON, Lorin, A., III [US/US]; US (UsOnly)
BOY, Kenneth, M. [US/US]; US (UsOnly)
GUERNON, Jason, M. [US/US]; US (UsOnly)
HIGGINS, Mendi, A. [US/US]; US (UsOnly)
SHI, Jianliang [US/US]; US (UsOnly)
WU, Yong-Jin [CA/US]; US (UsOnly)
ZHANG, Yunhui [US/US]; US (UsOnly)
MACOR, John, E. [US/US]; US (UsOnly)
Inventors:
MARCIN, Lawrence, R.; US
THOMPSON, Lorin, A., III; US
BOY, Kenneth, M.; US
GUERNON, Jason, M.; US
HIGGINS, Mendi, A.; US
SHI, Jianliang; US
WU, Yong-Jin; US
ZHANG, Yunhui; US
MACOR, John, E.; US
Agent:
MINGO, Pamela, A.; Bristol-Myers Squibb Company P.O. Box 4000 Princeton, New Jersey 08543-4000, US
Priority Data:
61/145,31916.01.2009US
Title (EN) BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
(FR) COMPOSÉS BICYCLIQUES DESTINÉS À LA RÉDUCTION DE LA PRODUCTION DE BÉTA-AMYLOÏDES
Abstract:
(EN) The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production, wherein A is a five- or six-membered heteroaromatic ring containing from one to three heteroatoms independently selected from nitrogen, oxygen, and sulfur; B is selected from phenyl and pyridinyl, D is selected from (II) E is selected from Ci-ealkyl, d-ecycloalkyl, benzyl, phenyl, and a five- to six- membered heteroaromatic ring containing one or two nitrogen atoms.
(FR) La présente invention concerne une série de composés de formule (I) qui réduisent la production en peptides β-amyloïdes (β-AP) et sont utiles dans le traitement de la maladie d'Alzheimer et d'autres états pathologiques affectés par la production en peptides β-amyloïdes (β-AP), dans lesquels A représente un cycle hétéroaromatique à cinq ou six chaînons contenant un à trois hétéroatomes indépendamment choisis parmi un azote, un oxygène, et du soufre; B est choisi parmi un phényle et un pyridinyle, D est choisi parmi (II), E est choisi parmi un Ci-ealkyle, un d-ecycloalkyle, un benzyle, un phényle, et un cycle hétéroaromatique ayant cinq à six chaînons contenant un ou deux atomes d'azote.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AR075139EP2379553JP2012515205CN102356081ES2426023IN4927/DELNP/2011