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1. (WO2010083121) BIOMARKER PANEL FOR DIAGNOSIS AND PREDICTION OF GRAFT REJECTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/083121 International Application No.: PCT/US2010/020599
Publication Date: 22.07.2010 International Filing Date: 11.01.2010
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, California 94306-1106, US (AllExceptUS)
SARWAL, Minnie M. [GB/US]; US (UsOnly)
Inventors:
SARWAL, Minnie M.; US
Agent:
SCHERER, David C.; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, CA 94303, US
Priority Data:
61/145,05915.01.2009US
Title (EN) BIOMARKER PANEL FOR DIAGNOSIS AND PREDICTION OF GRAFT REJECTION
(FR) PANEL DE BIOMARQUEURS POUR LE DIAGNOSTIC ET LA PRÉDICTION D'UN REJET DE GREFFON
Abstract:
(EN) Methods are provided for monitoring a subject having a graft for an acute rejection (AR) response, e.g., to predict, to diagnose, and/or to characterize an AR response. In practicing the subject methods, the expression level of at least one gene in a sample from the subject, e.g., a blood or biopsy sample, is evaluated, e.g., at the nucleic acid and/or protein level, to monitor the subject. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
(FR) La présente invention concerne des méthodes de surveillance d'une réponse de rejet aigu (RA) chez un sujet bénéficiant d'une greffe, par exemple pour prédire, diagnostiquer et/ou caractériser une réponse RA. Dans la pratique des méthodes selon l'invention, le niveau d'expression d'au moins un gène dans un échantillon du sujet, par exemple un échantillon de sang ou de biopsie, est évalué, par exemple au niveau des acides nucléiques et/ou des protéines, pour surveiller le sujet. La présente invention concerne également des compositions, des systèmes, des kits et des programmes informatiques utiles à la mise en œuvre des méthodes selon l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2387618US20120040358CN102439172ES2492498IN5546/CHENP/2011