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1. (WO2010082821) METHOD OF TREATING CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/082821 International Application No.: PCT/NL2010/050016
Publication Date: 22.07.2010 International Filing Date: 13.01.2010
Chapter 2 Demand Filed: 12.11.2010
IPC:
A61K 31/517 (2006.01) ,A61K 31/395 (2006.01) ,A61K 45/06 (2006.01) ,A61P 3/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM [NL/NL]; Meibergdreef 9 NL-1105 AZ Amsterdam, NL (AllExceptUS)
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM [NL/NL]; Dr. Molewaterplein 50 NL-3015 GE Rotterdam, NL (AllExceptUS)
KRAWCZYK, Przemyslaw [PL/NL]; NL (UsOnly)
ATEN, Jacob A. [NL/NL]; NL (UsOnly)
KANAAR, Roland [NL/NL]; NL (UsOnly)
ESSERS, Jeroen [NL/NL]; NL (UsOnly)
Inventors:
KRAWCZYK, Przemyslaw; NL
ATEN, Jacob A.; NL
KANAAR, Roland; NL
ESSERS, Jeroen; NL
Agent:
HATZMANN, M.J.; Vereenigde Johan de Wittlaan 7 NL-2517 JR Den Haag, NL
Priority Data:
PCT/NL2009/05000713.01.2009NL
Title (EN) METHOD OF TREATING CANCER
(FR) PROCÉDÉ DE TRAITEMENT DU CANCER
Abstract:
(EN) The present invention relates to a method of treating or preventing hyperproliferative disease in a body tissue of a subject, comprising the steps of administering to a subject in need thereof a therapeutically effective amount of an agent that induces double strand breaks in the DNA of the hyperproliferative cells of said body tissue; and subjecting the hyperproliferative cells of said body tissue prior to, simultaneously with or subsequent to step a) to hyperthermia to thereby induce in said cells the degradation, inhibition and/or inactivation of BRCA2.
(FR) La présente invention porte sur un procédé de traitement ou de prévention d'une maladie hyperproliférative dans un tissu corporel chez un sujet, comprenant les étapes suivantes: administrer à un sujet qui en a besoin une quantité thérapeutiquement efficace d'un agent induisant des ruptures bicaténaires dans l'ADN des cellules hyperprolifératives dudit tissu corporel; et soumettre à une hyperthermie les cellules hyperprolifératives dudit tissu corporel avant, pendant ou après l'étape précédente, pour induire ainsi dans lesdites cellules la dégradation, l'inhibition et l'inactivation de BRCA2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2387403US20120022026CN102316869CA2749424IN5008/CHENP/2011