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1. (WO2010082216) NOVEL SALTS OF SIBUTRAMINE AND THEIR CRYSTAL FORMS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/082216 International Application No.: PCT/IN2009/000705
Publication Date: 22.07.2010 International Filing Date: 07.12.2009
IPC:
C07C 211/29 (2006.01) ,C07C 209/82 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
26
of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
29
the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
82
Purification; Separation; Stabilisation; Use of additives
Applicants:
MATRIX LABORATORIES LTD [IN/IN]; 1-1-151/1/, IV Floor Sairam Towers Alexander Road Secunderabad 500 003, IN (AllExceptUS)
JETTI, Ramakoteswara Raro [IN/IN]; IN (UsOnly)
BHAGAVATULA, Neelima [IN/IN]; IN (UsOnly)
AGGI, Ramireddy Bommareddy [IN/IN]; IN (UsOnly)
DATTA, Debashish [IN/IN]; IN (UsOnly)
Inventors:
JETTI, Ramakoteswara Raro; IN
BHAGAVATULA, Neelima; IN
AGGI, Ramireddy Bommareddy; IN
DATTA, Debashish; IN
Priority Data:
3084/CHE/200808.12.2008IN
Title (EN) NOVEL SALTS OF SIBUTRAMINE AND THEIR CRYSTAL FORMS
(FR) NOUVEAUX SELS DE SIBUTRAMINE ET LEURS FORMES CRISTALLINES
Abstract:
(EN) The present invention relates to novel acid addition salt of Sibutramine, [1-(4- chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-cyclobutane-ethanamine] Sibutramine Maleate and the processes for their preparation.The present invention further relates to novel polymorphic forms of Sibutramine Fumarate, which include an anhydrate (Form-I), dihydrate (Form-II) and an amorphousform.
(FR) La présente invention concerne un nouveau sel d'addition acide de la Sibutramine [l-(4-chlorophényl)-N,N-diméthyl-a-(2-méthylpropyl)-cyclobutane-éthanamine], le maléate de Sibutramine, et son procédé de synthèse. La présente invention concerne en outre de nouvelles formes polymorphiques du fumarate de Sibutramine, qui incluent un anhydrate (Forme I), un dihydrate (Forme II) et une forme amorphe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)