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1. (WO2010082214) FENOFIBRATE FORMULATION WITH ENHANCED ORAL BIOAVAILABILITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/082214 International Application No.: PCT/IN2009/000365
Publication Date: 22.07.2010 International Filing Date: 26.06.2009
IPC:
A61K 9/48 (2006.01) ,A61K 31/216 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
Applicants:
PANACEA BIOTEC LIMITED [IN/IN]; Plot No. GEN -72/3, TTC Industrial Area Opp Millennium Business Park Gate No 2 Mahape Navi Mumbai 400 710 Maharashtra, IN (AllExceptUS)
JAIN, Rajesh [IN/IN]; IN (UsOnly)
SINGH, Sarabjit [IN/IN]; IN (UsOnly)
JAIN, Naveen [IN/IN]; IN (UsOnly)
PUTHLI, Shivanand; IN (UsOnly)
Inventors:
JAIN, Rajesh; IN
SINGH, Sarabjit; IN
JAIN, Naveen; IN
PUTHLI, Shivanand; IN
Priority Data:
1384/MUM/200803.07.2008IN
Title (EN) FENOFIBRATE FORMULATION WITH ENHANCED ORAL BIOAVAILABILITY
(FR) FORMULATION DE FÉNOFIBRATE À BIODISPONIBILITÉ ORALE OPTIMISÉE
Abstract:
(EN) The present invention provides a formulation of fenofibrate with enhanced oral bioavailability, simplicity of design and manufacture and absence of food effect. The formulation comprises fenofibrate dissolved in a lipophilic surfactant, with a hydrophilic surfactant optionally added. The formulation can be effectively used in the management and treatment of conditions such as hypertriglyceridemia, hypercholesterolemia and mixed dyslipidemia, and can also be effective at lower doses as compared to commercially available products. The invention additionally relates to the process of manufacture of the formulation and to dosage forms comprising the same.
(FR) La présente invention porte sur une formulation de fénofibrate à biodisponibilité orale optimisée, de conception et de fabrication simples, et dépourvue d'effet alimentaire. La formulation renferme du fénofibrate dissous dans un tensioactif lipophile, un tensioactif hydrophile pouvant éventuellement être ajouté. La formulation peut être utilisée efficacement dans la gestion et le traitement d'états pathologiques tels que l'hypertriglycéridémie, l'hypercholestérolémie et la dyslipidémie mixte, et se révèle en outre efficace à des doses inférieures par rapport aux produits disponibles dans le commerce. L'invention porte en outre sur le procédé de fabrication de la formulation, ainsi que sur des formes posologiques la renfermant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ590024EP2306989MXMX/a/2010/014200JP2011526621US20110160274RU2011103066
CN102083422CA2729262KR1020110027778BRPI0913940AU2009337465