Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010082108) IMPROVED PROCESS FOR PREPARATION OF KEY INTERMEDIATE OF CEPHALOSPORINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/082108 International Application No.: PCT/IB2010/000036
Publication Date: 22.07.2010 International Filing Date: 12.01.2010
IPC:
C07D 501/04 (2006.01) ,C07D 501/22 (2006.01) ,C07D 501/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
02
Preparation
04
from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14
Compounds having a nitrogen atom directly attached in position 7
16
with a double bond between positions 2 and 3
20
7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
22
with radicals containing only hydrogen and carbon atoms, attached in position 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14
Compounds having a nitrogen atom directly attached in position 7
16
with a double bond between positions 2 and 3
20
7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24
with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Applicants:
NECTAR LIFESCIENCES LTD. [IN/IN]; Village Saidpura Tehsil Derabassi Distt. Mohali 140 507 Punjab, IN (AllExceptUS)
SAHOO, Prabhat, Kumar [IN/IN]; IN (UsOnly)
SHRIVASTAVA, Ajay, Kumar [IN/IN]; IN (UsOnly)
YADAV, Chhannu, Lal [IN/IN]; IN (UsOnly)
CHAUBEY, Bipin, Kumar [IN/IN]; IN (UsOnly)
Inventors:
SAHOO, Prabhat, Kumar; IN
SHRIVASTAVA, Ajay, Kumar; IN
YADAV, Chhannu, Lal; IN
CHAUBEY, Bipin, Kumar; IN
Agent:
TIWARI, Amrish; K & S Partners B.K. House, Plot No. 109, Sector-44 Gurgaon 122 002 Haryana, IN
Priority Data:
78/DEL/200916.01.2009IN
Title (EN) IMPROVED PROCESS FOR PREPARATION OF KEY INTERMEDIATE OF CEPHALOSPORINS
(FR) PROCÉDÉ AMÉLIORÉ DE PRÉPARATION D'UN INTERMÉDIAIRE CLÉ DE CÉPHALOSPORINES
Abstract:
(EN) An improved process for the preparation of 7-phenylacetamido-3-vinyl cephalosporanic acid-p-methoxybenzyl ester of formula (I), which is a key intermediate of cephalosporin antibiotics and is extremely useful in their synthesis, is provided. More particularly, an improved process for the preparation of a compound of formula (I) by using a compound of formula (A) is provided, wherein, R represents hydrogen, alkyl, aryl or arylalkyl, which may be same or different and may be further substituted, making it a substantially cost effective and eco-friendly procedure.
(FR) La présente invention concerne un procédé amélioré de préparation de d'ester p-méthoxybenzylique d'acide 7-phénylacétamido-3-vinyl céphalosporanique de formule (I), qui est un intermédiaire clé des céphalosporines et qui se révèle, donc, extrêmement utile dans le cadre de leur synthèse. La présente invention concerne, plus précisément, un procédé amélioré de préparation d'un composé de formule (I) au moyen d'un composé de formule (A), dans laquelle R représente hydrogène, alkyle, aryle ou arylalkyle, lesquels peuvent être identiques ou différents et peuvent en outre être substitués, ce qui en fait une procédure sensiblement économique et écologique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)