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1. (WO2010082004) METHODS FOR DETERMINING THE LIKELIHOOD OF A PATIENT CONTRACTING A NOSOCOMIAL INFECTION AND FOR DETERMINING THE PROGNOSIS OF THE COURSE OF A SEPTIC SYNDROME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/082004 International Application No.: PCT/FR2010/050070
Publication Date: 22.07.2010 International Filing Date: 18.01.2010
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
BIOMERIEUX [FR/FR]; Chemin de l'Orme F-69280 Marcy l'Etoile, FR (AllExceptUS)
HOSPICES CIVILS DE LYON [FR/FR]; 3, quai des Célestins F-69002 Lyon, FR (AllExceptUS)
CAZALIS, Marie-Angélique [FR/FR]; FR (UsOnly)
LEPAPE, Alain [FR/FR]; FR (UsOnly)
MONNERET, Guillaume [FR/FR]; FR (UsOnly)
MOUGIN, Bruno [FR/FR]; FR (UsOnly)
PACHOT, Alexandre [FR/FR]; FR (UsOnly)
Inventors:
CAZALIS, Marie-Angélique; FR
LEPAPE, Alain; FR
MONNERET, Guillaume; FR
MOUGIN, Bruno; FR
PACHOT, Alexandre; FR
Agent:
DORGET, Elisabeth; BioMérieux Département Propriété Industrielle Chemin de l'Orme F-69280 Marcy l'Etoile, FR
Priority Data:
095030519.01.2009FR
095030619.01.2009FR
Title (EN) METHODS FOR DETERMINING THE LIKELIHOOD OF A PATIENT CONTRACTING A NOSOCOMIAL INFECTION AND FOR DETERMINING THE PROGNOSIS OF THE COURSE OF A SEPTIC SYNDROME
(FR) PROCEDES POUR DETERMINER LA SUSCEPTIBILITE A CONTRACTER UNE INFECTION NOSOCOMIALE CHEZ UN PATIENT ET POUR ETABLIR UN PRONOSTIC D'EVOLUTION D'UN SYNDROME SEPTIQUE
Abstract:
(EN) The present invention relates to a method for determining the likelihood of a patient contracting a nosocomial infection and to a method for determining the prognosis of the course of a septic syndrome in a patient, according to which: a. a biological sample is obtained from the patient and biological material is extracted from the biological sample; b. at least one specific reagent is obtained from an expression construct of at least one target gene selected from target genes S100A9 and S100A8; c. the expression of at least one of the target genes S100A9 and S100A8 is determined, an overexpression relative to a predetermined threshold value indicating the likelihood of contracting a nosocomial infection as well as indicating a poor prognosis of the course of a septic syndrome.
(FR) La présente invention concerne un procédé pour déterminer la susceptibilité à contracter une infection nosocomiale chez un patient et un procédé pour l'établissement d'un pronostic d'évolution d'un syndrome septique chez un patient selon lesquels : a. on dispose d'un échantillon biologique du patient et on extrait du matériel biologique de l'échantillon biologique; b. on dispose d'au moins un réactif spécifique d'un produit d'expression d'au moins un gène cible choisi parmi les gènes cibles S100A9 et S100A8; c. on détermine l'expression d'au moins un des gènes cibles S100A9 et S100A8, une surexpression par rapport à une valeur seuil déterminée étant une indication d'une susceptibilité à contracter une infection nosocomiale et une indication d'un mauvais pronostic d'évolution d'un syndrome septique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP2379752JP2012514993US20110250592CN102301008RU2011134644RU0002525707
KR1020110111491ES2556771BRPI1006850KR1020180026561