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1. (WO2010081874) NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081874 International Application No.: PCT/EP2010/050452
Publication Date: 22.07.2010 International Filing Date: 15.01.2010
IPC:
C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
ALEMPARTE-GALLARDO, Carlos [ES/ES]; ES (UsOnly)
BARROS-AGUIRRE, David [ES/ES]; ES (UsOnly)
CACHO-IZQUIERDO, Monica [ES/ES]; ES (UsOnly)
FIANDOR-ROMAN, Jose Maria [ES/ES]; ES (UsOnly)
LAVANDERA DIAZ, Jose Luis [ES/ES]; ES (UsOnly)
REMUINAN-BLANCO, Modesto Jesus [ES/ES]; ES (UsOnly)
Inventors:
ALEMPARTE-GALLARDO, Carlos; ES
BARROS-AGUIRRE, David; ES
CACHO-IZQUIERDO, Monica; ES
FIANDOR-ROMAN, Jose Maria; ES
LAVANDERA DIAZ, Jose Luis; ES
REMUINAN-BLANCO, Modesto Jesus; ES
Agent:
WALKER, Ralph Francis; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
09382116.317.07.2009EP
PCT/EP2009/05043615.01.2009EP
Title (EN) NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS
(FR) COMPOSÉS NAPHTHYRIDINE-2(1H)-ONE UTILES COMME ANTIBACTÉRIENS
Abstract:
(EN) Compounds of Formula (I) wherein substituents R1, R2 and R5 are as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl substituted by a hydroxyalkyl substituent and an optional other substituent; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
(FR) La présente invention concerne des composés de formule (I), dans laquelle les substituants R1, R2 et R5 sont tel que défini, et Ar représente un phényle substitué, un pyridyle, un pyridazinyle, un pyrimidinyle, un pyrazinyle, un thiazolyle, un furanyle, un imidazolyle et un thiophényle substitués par un substituant hydroxyalkyle et éventuellement un autre substituant; des compositions les contenant, leur utilisation en thérapie, y compris leur utilisation comme antibactériens, par exemple dans le traitement de la tuberculose. L'invention concerne également des procédés de préparation de tels composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379554JP2012515188US20120115899ES2561631