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1. (WO2010081787) IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081787 International Application No.: PCT/EP2010/050234
Publication Date: 22.07.2010 International Filing Date: 11.01.2010
IPC:
C07K 16/28 (2006.01) ,A61K 39/395 (2006.01) ,A61K 47/48 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
DOMANTIS LIMITED [GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS, GB (AllExceptUS)
BREWIS, Neil [GB/GB]; GB (UsOnly)
HOLMES, Steve [GB/GB]; GB (UsOnly)
Inventors:
BREWIS, Neil; GB
HOLMES, Steve; GB
Agent:
CLUBE, Jasper, Rupert; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
61/144,58314.01.2009US
Title (EN) IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS
(FR) ANTAGONISME AMÉLIORÉ DU TNFΑ, PROPHYLAXIE ET THÉRAPIE AVEC NÉCROSE D'ORGANE RÉDUITE
Abstract:
(EN) The invention relates to anti-TNFR1 polypeptides, binding moieties, antibody single variable domains (dAbs) and antagonists for treating and/or preventing a TNFα-mediated condition in a patient and substantially protecting against TNFα-mediated organ necrosis. The invention also relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) and antagonists for antagonising TNFα in a patient and substantially protecting against TNFα-mediated organ necrosis. Methods and uses are also provided. Thus, liver, kidney, heart, pancreas, lung and/or other organs are substantially protected while TNFα is addressed using the approach of the invention.
(FR) La présente invention porte sur des polypeptides, des fractions liantes, des domaines variables uniques d'anticorps (dAb) et des antagonistes anti-TNFR1 destinés à traiter et/ou prévenir une affection médiée par le TNFα chez un patient, et protéger sensiblement contre une nécrose d'organe médiée par le TNFα. L'invention porte également sur des polypeptides, des domaines variables uniques d'anticorps (dAb) et des antagonistes anti-TNFR1 destinés à antagoniser le TNFα chez un patient et protéger sensiblement contre une nécrose d'organe médiée par le TNFα. Des méthodes et des utilisations sont également décrites. Ainsi, le foie, les reins, le cœur, le pancréas, les poumons et/ou d'autres organes sont sensiblement protégés tandis que le TNFα est ciblé par l'approche de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)