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1. (WO2010081683) NOVEL EICOSANOID DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081683 International Application No.: PCT/EP2010/000140
Publication Date: 22.07.2010 International Filing Date: 13.01.2010
IPC:
C07C 235/76 (2006.01) ,C07C 275/20 (2006.01) ,C07D 303/38 (2006.01) ,A61K 31/336 (2006.01) ,A61K 31/16 (2006.01) ,A61K 31/19 (2006.01) ,A61P 9/12 (2006.01) ,A61P 9/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
70
having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
72
with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
76
of an unsaturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04
having nitrogen atoms of urea groups bound to acyclic carbon atoms
20
of an unsaturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
303
Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02
Compounds containing oxirane rings
38
with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
336
having three-membered rings, e.g. oxirane, fumagillin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
08
Vasodilators for multiple indications
Applicants:
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (MDC) [DE/DE]; Robert-Rössle-Str. 10 13125 Berlin, DE (AllExceptUS)
SCHUNCK, Wolf-Hagen [DE/DE]; DE (UsOnly)
WALLUKAT, Gerd [DE/DE]; DE (UsOnly)
FISCHER, Robert [DE/DE]; DE (UsOnly)
SCHMIDT, Cosima [DE/DE]; DE (UsOnly)
MÜLLER, Dominik, N. [DE/DE]; DE (UsOnly)
PULI, Narender [US/US]; US (UsOnly)
FALCK, John, R. [US/US]; US (UsOnly)
Inventors:
SCHUNCK, Wolf-Hagen; DE
WALLUKAT, Gerd; DE
FISCHER, Robert; DE
SCHMIDT, Cosima; DE
MÜLLER, Dominik, N.; DE
PULI, Narender; US
FALCK, John, R.; US
Agent:
FORSTMEYER, Dietmar; Boeters & Lieck Oberanger 32 80331 Munich, DE
Priority Data:
09000372.413.01.2009EP
Title (EN) NOVEL EICOSANOID DERIVATIVES
(FR) NOUVEAUX DÉRIVÉS D'ÉICOSANOÏDES
Abstract:
(EN) The present invention provides compounds (n-3 PUFA derivatives) of formula (I) that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.
(FR) La présente invention concerne des composés (dérivés PUFA n-3) de formule (I) qui modulent des états associés aux lésions cardiaques, et en particulier aux arythmies cardiaques.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2208720EP2376432JP2012515177US20120122972CN102348678CA2749840
KR1020110103471US20160326128AU2010205816DK2376432EP3222612ES2633315
IN5013/CHENP/2011