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1. (WO2010081488) NITRIC OXIDE FUROXAN DERIVATIVE COMPOUNDS ENDOWED WITH ANTITUMORAL ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081488 International Application No.: PCT/EP2009/000206
Publication Date: 22.07.2010 International Filing Date: 15.01.2009
IPC:
C07D 271/10 (2006.01) ,C07D 498/04 (2006.01) ,A61P 35/04 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/4245 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
271
Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02
not condensed with other rings
10
1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
Applicants:
HUMANITAS MIRASOLE S.P.A. [IT/IT]; Via Manzoni, 56 I-20089 Rozzano Milano, IT (AllExceptUS)
ISTITUTO ONCOLOGICO VENETO IRCCS [IT/IT]; Via Gattamelata, 64 I-35128 Padova, IT (AllExceptUS)
VIOLA, Antonella [IT/IT]; IT (UsOnly)
BRONTE, Enzo [IT/IT]; IT (UsOnly)
CROSETTI, Marco [IT/IT]; IT (UsOnly)
LAZZARATO, Loretta [IT/IT]; IT (UsOnly)
FRUTTERO, Roberta [IT/IT]; IT (UsOnly)
GASCO, Alberto [IT/IT]; IT (UsOnly)
Inventors:
VIOLA, Antonella; IT
BRONTE, Enzo; IT
CROSETTI, Marco; IT
LAZZARATO, Loretta; IT
FRUTTERO, Roberta; IT
GASCO, Alberto; IT
Agent:
LONG, Giorgio; Jacobacci & Partners S.p.A. Via Senato 8 I-20121 Milano, IT
Priority Data:
Title (EN) NITRIC OXIDE FUROXAN DERIVATIVE COMPOUNDS ENDOWED WITH ANTITUMORAL ACTIVITY
(FR) COMPOSÉS DÉRIVÉS DE FUROXANE LIBÉRANT DE L'OXYDE NITRIQUE DOTÉS D'UNE ACTIVITÉ ANTITUMORALE
Abstract:
(EN) The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as vaccines against tumors.
(FR) La présente invention porte sur des composés dérivés de furoxane libérant de l'oxyde nitrique qui s'avèrent être actifs dans le traitement de tumeurs. De plus, ils peuvent être utilisés comme vaccins contre des tumeurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)