Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010081408) BIOACTIVE TISSUE REGENERATION FILM AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081408 International Application No.: PCT/CN2010/070133
Publication Date: 22.07.2010 International Filing Date: 12.01.2010
IPC:
A61L 27/22 (2006.01) ,A61L 27/26 (2006.01) ,A61L 27/54 (2006.01) ,A61L 27/58 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
26
Mixtures of macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
54
Biologically active materials, e.g. therapeutic substances
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
Applicants:
武汉本药康华生物科技有限公司 PHARMINOVA BIOTECH CO., LTD. [CN/CN]; 中国湖北省武汉市 东湖开发区东信路数码港E幢 Building E, Digital Park, Dongxin Road, East Lake High-tech Development Zone Wuhan, Hubei 430074, CN (AllExceptUS)
张玉峰 ZHANG, Yufeng [CN/CN]; CN (UsOnly)
刘朝阳 LIU, Chaoyang [CN/CN]; CN (UsOnly)
马兆成 MA, Zhaocheng [CN/CN]; CN (UsOnly)
Inventors:
张玉峰 ZHANG, Yufeng; CN
刘朝阳 LIU, Chaoyang; CN
马兆成 MA, Zhaocheng; CN
Agent:
上海三和万国知识产权代理事务所 SANHE INTERNATIONAL IP ATTORNEYS; 中国上海市 莘闵高新技术暨归国留学生科技创业园金都路4299号D栋578号 Suite D-578 4299 Jindu Road, Xinmin New Hi-Tech & Returned Student Science Undertaking Zone Shanghai 201108, CN
Priority Data:
200910060497.513.01.2009CN
Title (EN) BIOACTIVE TISSUE REGENERATION FILM AND PREPARATION METHOD THEREOF
(FR) FILM BIOACTIF POUR LA RÉGÉNÉRATION TISSULAIRE ET PROCÉDÉ DE PRÉPARATION CORRESPONDANT
(ZH) 一种生物活性组织再生膜及其制备方法
Abstract:
(EN) Provided is a double-deck composite structured bioactive tissue regeneration film which has a tissue isolation layer consisting of silk fibroins, and a tissue induction layer adhered to the tissue isolation layer, which consists of silk fibroin beams or silk fibroin beams mixed with biological active factors. The film is smooth and dense on one side, with loose porous structure on the other side. A method for preparing the bioactive tissue regeneration film is also provided. The method comprises the following steps: the silk fibroin solution is swollen, stirred, deaired and casted into film; one side of the film is scratched to be coarsened; the silk fibroin solution or the silk fibroin solution mixed with biological active factors is coated on the scratched side; the film is obtained after freezing, vacuum drying and demoulding. The film is nontoxic and harmless, has perfect biocompatibility, promote the adherence and growth of cells, and can be used for substituting collagen in clinical medicine.
(FR) La présente invention concerne un film bioactif pour la régénération tissulaire à structure composite double, comprenant une couche d'isolation tissulaire constituée de fibroïnes de soie et une couche d'induction tissulaire collée à la couche d'isolation tissulaire, constituée de faisceaux de fibroïnes de soie ou de faisceaux de fibroïnes de soie mélangés à des facteurs biologiques actifs. Le film est lisse et dense sur une face, et présente une structure lâche et poreuse sur l'autre face. L'invention porte également sur un procédé de préparation dudit film bioactif pour la régénération tissulaire. Le procédé comprend les étapes suivantes : la solution de fibroïnes de soie est gonflée, brassée, désaérée, puis coulée pour former un film; une face du film est égratignée pour la rendre rugueuse; la solution de fibroïnes de soie ou la solution de fibroïnes de soie mélangée à des facteurs biologiques actifs forme un revêtement sur la face égratignée; le film est obtenu après congélation, séchage sous vide et démoulage. Ledit film est non toxique et inoffensif, possède une biocompatibilité parfaite, favorise l'adhérence et la croissance cellulaires, et peut être utilisé pour remplacer le collagène en médecine clinique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)