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1. (WO2010081286) TIMING CONTROLLED – RELEASE POROUS TABLET OF DILTIAZEM HYDROCHLORIDE AND THE PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081286 International Application No.: PCT/CN2009/001575
Publication Date: 22.07.2010 International Filing Date: 29.12.2009
IPC:
A61K 9/30 (2006.01) ,A61K 31/554 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
30
Organic coatings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
554
having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
Applicants:
北京科信必成医药科技发展有限公司 BEIJING KEXIN BICHENG BIOMEDICAL TECHNOLOGY DEVELOPMENT CO., LTD. [CN/CN]; 中国北京市海淀区知春路63号卫星大厦1410室, Beijing 100190 Room 1410, Weixing Building No. 63, Zhichun Road Haidian District Beijing 100190, CN (AllExceptUS)
蒋海松 JIANG, Haison [CN/CN]; CN (UsOnly)
王锦刚 WANG, Jingang [CN/CN]; CN (UsOnly)
Inventors:
蒋海松 JIANG, Haison; CN
王锦刚 WANG, Jingang; CN
Agent:
中国专利代理(香港)有限公司 CHINA PATENT AGENT (H.K.) LTD.; 中国香港特别行政区湾仔港湾道23号鹰君中心22号楼 22/F, Great Eagle Centre 23 Harbour Road Wanchai Hong Kong, CN
Priority Data:
200810246731.930.12.2008CN
Title (EN) TIMING CONTROLLED – RELEASE POROUS TABLET OF DILTIAZEM HYDROCHLORIDE AND THE PREPARATION METHOD THEREOF
(FR) COMPRIMÉ POREUX À LIBÉRATION AVEC COMMANDE DE TEMPORISATION DE CHLORHYDRATE DE DILTIAZEM ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 群孔释放的盐酸地尔硫卓择时控释片及其制备方法
Abstract:
(EN) A timing controlled-release porous tablet of diltiazem hydrochloride and the preparation method thereof. The tablet is composed of a core and a release rate controlling membrane, wherein the core comprises diltiazem hydrochloride, a filler, and an osmotic pressure active agent, and the release rate controlling membrane comprises a film-forming material and a pore-forming agent. The pore-forming agent is present in an amount of 19-30wt% by weight of the release rate controlling membrane, and the release rate controlling membrane is present in an amount of 15-25wt% by weight of the core. The drug release from the tablet starts at 4 hours after administration and is completed within 24 hours.
(FR) L'invention porte sur un comprimé poreux à libération avec commande de temporisation de chlorhydrate de diltiazem et sur son procédé de préparation. Le comprimé est composé d'un noyau et d'une membrane commandant la vitesse de libération, le noyau comprenant du chlorhydrate de diltiazem, une charge et un agent actif à pression osmotique, et la membrane commandant la vitesse de libération comprenant un matériau formant un film et un agent de formation de pores. L'agent de formation de pores est présent selon une valeur de 19 à 30 % en poids de la membrane commandant la vitesse de libération, et la membrane commandant la vitesse de libération est présente selon une valeur de 15 à 25 % en poids du noyau. La libération de médicament à partir du comprimé démarre 4 heures après l'administration et est achevée en l'espace de 24 heures.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)