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1. (WO2010081204) POLYAMINE ACTIVATORS ( S PERMINE, S PERMIDINE) OF THE AUTOPHAGIC PATHWAY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081204 International Application No.: PCT/BE2010/000002
Publication Date: 22.07.2010 International Filing Date: 14.01.2010
IPC:
A61K 31/132 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
132
having two or more amino groups, e.g. spermidine, putrescine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; K.U.Leuven R & D Minderbroedersstraat 8a - bus 5105 B-3000 Leuven, BE (AllExceptUS)
WINDERICKX, Joris [BE/BE]; BE (UsOnly)
EISENBERG, Tobias [DE/AT]; AT
KROEMER, Guido [DE/FR]; FR
MADEO, Frank [DE/AT]; AT
MINOIS, Nadege [FR/GB]; GB
ROCKENFELLER, Patrick [DE/AT]; AT
Inventors:
WINDERICKX, Joris; BE
EISENBERG, Tobias; AT
KROEMER, Guido; FR
MADEO, Frank; AT
MINOIS, Nadege; GB
ROCKENFELLER, Patrick; AT
Common
Representative:
KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; K.U.Leuven R & D Minderbroedersstraat 8a - bus 5105 B-3000 Leuven, BE
Priority Data:
0900514.114.01.2009GB
0920456.124.11.2009GB
103642715.01.2009NL
Title (EN) POLYAMINE ACTIVATORS ( S PERMINE, S PERMIDINE) OF THE AUTOPHAGIC PATHWAY
(FR) ACTIVATEURS DE LA VOIE AUTOPHAGE
Abstract:
(EN) A polyamine compound of the group consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidine phosphate hexahydrate, spermidine phosphate hexahydrate and 1, 4 -butanediamine N- (3 -aminopropyl) -monohydrochloride or derivatives thereof or combinations thereof which are effective to activate the cellularautophagic pathway for use in a treatment to increase the survivability, lifespan or the life expectancy of an invertebrate animal/poikilotherm invertebrate animal, or to increase the average lifespan of a population of such invertebrate animals.
(FR) Selon la présente invention, il a été clairement démontré que des composés polyamine des groupes ci-après : putrescine, spermine, spermidine, cholesteryl spermine, trihydrochlorure de spermidine, hexahydrate de spermidine phosphate, hexahydrate de spermidine phosphate et N-(3-aminopropyl)-monohydrochlorure de 1,4-butanediamine, ou bien des dérivés ou des combinaisons de ces substances, peuvent induire une déactétylation ou maintenir un état d'hypoacétylation de l'histone H3 et activer une autophagie. Ces composés peuvent donc être utilisés dans un traitement visant à activer ou à rétablir une voie autophagique normale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)