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1. (WO2010081172) METHODS FOR TREATING VASCULAR LEAK SYNDROME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081172 International Application No.: PCT/US2010/020817
Publication Date: 15.07.2010 International Filing Date: 12.01.2010
IPC:
A01N 43/82 (2006.01) ,A61K 31/41 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
72
having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms
82
five-membered rings with three hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
Applicants:
AKEBIA THERAPEUTICS INC. [US/US]; 9987 Carver Road Cincinnati, OH 45242, US (AllExceptUS)
SHALWITZ, Robert [US/US]; US (UsOnly)
PETERS, Kevin Gene [US/US]; US (UsOnly)
Inventors:
SHALWITZ, Robert; US
PETERS, Kevin Gene; US
Agent:
ECHLER, Richard, S.; FSB Legal Counsel 118 Highlands Drive Woodstock, GA 30188, US
Priority Data:
61/144,02212.01.2009US
61/184,98608.06.2009US
Title (EN) METHODS FOR TREATING VASCULAR LEAK SYNDROME
(FR) MÉTHODES DE TRAITEMENT DU SYNDROME DE FUITE VASCULAIRE
Abstract:
(EN) Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease. Yet further disclosed are methods for treating renal cell carcinoma and melanoma. Still further disclosed are methods for reducing metastasis of malignant cells and/or preventing the proliferation of carcinoma cells via spreading due to vascular leakage.
(FR) La présente invention concerne des méthodes de traitement du syndrome de fuite vasculaire. La présente invention concerne en outre des méthodes de traitement des fuites vasculaires dues aux maladies inflammatoires, entre autres sepsie, lupus, syndrome du côlon irritable. La présente invention concerne également des méthodes de traitement des mélanomes et des carcinomes à cellules rénales. La présente invention concerne en outre des méthodes de réduction des métastases de cellules malignes et/ou de prévention de la prolifération des cellules de carcinomes du fait de la fuite vasculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL214047SG172312EP2385763JP2012515169US20110268694CN102365023
RU2011133833CA2748814RU0002539917KR1020110114656BRPI1006898NZ594535
AU2010203352VN28774ID051.4657MYPI 2011003558TH139626IN4961/DELNP/2011
ES2675891IL248340IL261374