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1. (WO2010081111) MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/081111 International Application No.: PCT/US2010/020672
Publication Date: 15.07.2010 International Filing Date: 11.01.2010
IPC:
C12P 21/04 (2006.01) ,C12P 19/34 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
04
Cyclic or bridged peptides or polypeptides, e.g. bacitracin
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
26
Preparation of nitrogen-containing carbohydrates
28
N-glycosides
30
Nucleotides
34
Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Applicants:
SUTRO BIOPHARMA, INC. [US/US]; 310 Utah Street, Suite 150 South San Francisco, California 94080, US (AllExceptUS)
VOLOSHIN, Alexei M. [US/US]; US (UsOnly)
ZAWADA, James F. [US/US]; US (UsOnly)
GOLD, Daniel [US/US]; US (UsOnly)
MURRAY, Christopher, James [US/US]; US (UsOnly)
ROZZELLE, James, Edward [US/US]; US (UsOnly)
UTER, Nathan [US/US]; US (UsOnly)
YIN, Gang [US/US]; US (UsOnly)
Inventors:
VOLOSHIN, Alexei M.; US
ZAWADA, James F.; US
GOLD, Daniel; US
MURRAY, Christopher, James; US
ROZZELLE, James, Edward; US
UTER, Nathan; US
YIN, Gang; US
Agent:
CHEN, ShengFeng; Townsend and Townsend and Crew LLP Two Embarcadero Center, 8th Floor San Francisco, California 94111, US
Priority Data:
61/144,03012.01.2009US
61/144,08312.01.2009US
61/144,09712.01.2009US
Title (EN) MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM
(FR) SYSTÈME DE MONO-CHARGEMENT POUR L'INTRODUCTION SÉLECTIVE D'ACIDES AMINÉS NON NATIFS DANS DES PROTÉINES À L'AIDE D'UN SYSTÈME DE SYNTHÈSE DE PROTÉINES IN VITRO
Abstract:
(EN) This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.
(FR) La présente invention concerne un nouveau moyen d'incorporer des acides aminés non natifs en des positions présélectionnées d'une protéine à l'aide d'un système de synthèse hors cellule. Les méthodes impliquent l'emploi d'ARNt sens isoaccepteurs natifs codés par le code génétique. De telles méthodes permettent l'incorporation de nombreux acides aminés non natifs par emploi de codons sens sans dépendre de paires orthogonales ARNt-synthase.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2376647JP2012514979CN102348807IN5742/CHENP/2011