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1. (WO2010080863) ENHANCED NEOGLYCOSIDES THROUGH NEOGLYCOSYLATION AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/080863 International Application No.: PCT/US2010/020300
Publication Date: 15.07.2010 International Filing Date: 07.01.2010
IPC:
C07C 5/03 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
5
Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
02
by hydrogenation
03
of non-aromatic carbon-to-carbon double bonds
Applicants:
WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street Madison, WI 53705, US (AllExceptUS)
GOFF, Randal, D. [US/US]; US (UsOnly)
THORSON, Jon, Scott [US/US]; US (UsOnly)
Inventors:
GOFF, Randal, D.; US
THORSON, Jon, Scott; US
Agent:
LIN, Jacquelyn, R.; Quarles & Brady LLP 411 E. Wisconsin Ave. Milwaukee, WI 53202, US
Priority Data:
61/143,06107.01.2009US
Title (EN) ENHANCED NEOGLYCOSIDES THROUGH NEOGLYCOSYLATION AND METHODS OF USE THEREOF
(FR) NÉO-GLYCOSIDES AMÉLIORÉS PAR NÉO-GLYCOSYLATION ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, based upon the appended sugar, into two distinct compound subsets.
(FR) A l'aide d'une néo-glycosylation, l'impact de la glycosylation différentielle sur les propriétés divergentes anti-cancer et anti-VIH du triterpénoïde acide bétulinique (BA) a été examiné. Chaque élément d'une bibliothèque de 37 variants de BA, glycosylés de façon différentielle, a été testé pour les activités anti-cancer et anti-VIH. Les analogues améliorés pour les deux activités désirées ont été découverts avec les améliorations antitumorales ou antivirales correspondantes, divergeant sur la base du sucre associé, en deux sous-ensembles distincts de composés.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120108530