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1. (WO2010080720) CONJUGATES OF A LYSOSOMAL ENZYME MOIETY AND A WATER SOLUBLE POLYMER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/080720 International Application No.: PCT/US2010/000078
Publication Date: 15.07.2010 International Filing Date: 12.01.2010
IPC:
A61K 47/48 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
NEKTAR THERAPEUTICS [US/US]; 455 Mission Bay Boulevard South Suite 100 San Francisco, CA 94158, US (AllExceptUS)
BOSSARD, Mary, J. [US/US]; US (UsOnly)
Inventors:
BOSSARD, Mary, J.; US
Agent:
WILSON, Mark, A.; Nektar Therapeutics 455 Mission Bay Boulevard South Suite 100 San Francisco, CA 94158, US
Priority Data:
61/205,05912.01.2009US
Title (EN) CONJUGATES OF A LYSOSOMAL ENZYME MOIETY AND A WATER SOLUBLE POLYMER
(FR) CONJUGUÉS D'UNE FRACTION ENZYMATIQUE LYSOSOMALE ET POLYMÈRE SOLUBLE DANS L'EAU
Abstract:
(EN) Conjugates of a lysosomal enzyme moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is a poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising such conjugates, methods of making the conjugates, and methods of administering the compositions to a patient, e.g., for treatment of a lysosomal storage disease.
(FR) L'invention porte sur des conjugués d'une fraction enzymatique lysosomale et d'un ou plusieurs polymères solubles dans l'eau non peptidiques. En général, le polymère soluble dans l'eau non peptidique est un poly(éthylène glycol) ou un dérivé correspondant. L'invention porte, entre autres, sur des compositions renfermant de tels conjugués, sur des procédés de production des conjugués et sur des procédés d'administration des compositions à un patient, par exemple pour le traitement d'une maladie du stockage lysosomal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20110318322