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1. (WO2010080484) METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE MOLECULAR WEIGHT USING CARBON
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/080484 International Application No.: PCT/US2009/068424
Publication Date: 15.07.2010 International Filing Date: 17.12.2009
IPC:
C12N 1/20 (2006.01) ,C12P 19/04 (2006.01) ,A61K 39/09 (2006.01) ,C08B 37/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
04
Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
09
Streptococcus
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
B
POLYSACCHARIDES; DERIVATIVES THEREOF
37
Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
Applicants:
WYETH LLC [US/US]; Patent Law Department Five Giralda Farms Madison, NJ 07940, US (AllExceptUS)
CRINEAN, Jean, Heather [US/US]; US (UsOnly)
Inventors:
CRINEAN, Jean, Heather; US
Agent:
ZAHNER, Joseph, E.; Wyeth Patent Law Department Five Giralda Farms Madison, NJ 07940, US
Priority Data:
61/138,57018.12.2008US
Title (EN) METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE MOLECULAR WEIGHT USING CARBON
(FR) PROCÉDÉ DE CONTRÔLE DU POIDS MOLÉCULAIRE D'UN POLYSACCHARIDE PROVENANT DE STREPTOCOCCUS PNEUMONIAE EN UTILISANT DU CARBONE
Abstract:
(EN) The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular polysaccharides having phosphodiester linkages between saccharide repeat units. In certain methods, CO2 is supplied to a fermentation culture of Streptococcus pneumoniae bacterial cells that produce capsular polysaccharide serotypes containing phosphodiester linkages between saccharide repeat units. Exemplary Streptococcus pneumoniae serotypes containing a phosphodiester linkage between saccharide repeat units include serotypes 6A, 6B, 19A, and 19F. Supplying CO2 to the fermentation culture includes adding bicarbonate ions to the fermentation culture, adding carbonate ions to the fermentation culture, adding mixtures of bicarbonate and carbonate ions to the fermentation culture, and overlaying the fermentation culture with CO2.
(FR) La présente invention concerne des procédés améliorés de production d'une solution contenant des polysaccharides capsulaires de poids moléculaire élevé isolés de Streptococcus pneumoniae ayant des liaisons phosphodiester entre les unités répétées de saccharides. Dans certains procédés, le CO2 est alimenté dans une culture en fermenteur des cellules bactériennes de Streptococcus pneumoniae qui produisent des sérotypes de polysaccharides capsulaires contenant des liaisons phosphodiester entre les unités répétées de saccharides. Des sérotypes exemplaires de Streptococcus pneumoniae contenant une liaison phosphodiester entre les unités répétées de saccharides comprennent les sérotypes 6A, 6B, 19A, et 19F. L'alimentation de la culture en fermenteur en CO2 comprend l'ajout d'ions bicarbonate à la culture en fermenteur, l'ajout d’ions carbonate à la culture en fermenteur, l'ajout de mélanges d'ions bicarbonate et carbonate à la culture en fermenteur, et le recouvrement de la culture en fermenteur avec du CO2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL213215MXMX/a/2011/006431EP2385981JP2012512659CN102257127RU2011124143
CA2743708MX346071KR1020110091548JP2015144614BRPI0923165AU2009335824
IN3624/DELNP/2011