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1. (WO2010080455) NEW SALTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/080455 International Application No.: PCT/US2009/068352
Publication Date: 15.07.2010 International Filing Date: 17.12.2009
IPC:
C07D 205/04 (2006.01) ,A61K 31/397 (2006.01) ,A61P 29/00 (2006.01) ,A61P 31/06 (2006.01) ,A61P 31/08 (2006.01) ,A61P 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
205
Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
397
having four-membered rings, e.g. azetidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
06
for tuberculosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
08
for leprosy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
DE LA CRUZ, Marilyn [US/US]; US (UsOnly)
KARPINSKI, Piotr, H. [US/US]; US (UsOnly)
LIU, Yugang [US/US]; US (UsOnly)
Inventors:
DE LA CRUZ, Marilyn; US
KARPINSKI, Piotr, H.; US
LIU, Yugang; US
Agent:
HOUGHTON, Gregory; NOVARTIS Patent Department One Health Plaza East Hanover, NJ 07936-1080, US
Priority Data:
61/203,05118.12.2008US
Title (EN) NEW SALTS
(FR) NOUVEAUX SELS
Abstract:
(EN) This invention relates to a hydrochloride, malafe, oxalate and tartrate salt forms of 1-(4- { 1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyI)-azetidine- 3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
(FR) L'invention porte sur des formes de sel chlorhydrate, malate, oxalate et tartrate d'acide 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxyimino]-éthyl}-2-éthyl-benzyl)-azétidine-3-carboxylique (composé I), sur des compositions pharmaceutiques renfermant ce sel, sur des procédés pour former ce sel et sur son utilisation dans un traitement médical. De plus, la présente invention porte également sur de nouvelles formes polymorphes de chacun de ces sels, ainsi que sur des compositions pharmaceutiques renfermant ces formes polymorphes, sur des procédés pour les obtenir et sur leurs utilisations dans un traitement médical.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2011/006622EP2379499JP2012512885US20110257150CN102256941CN103204794
RU2011129229CA2747558ES2478842MX2011006622KR1020110101159AU2009335887
AU2013231122IN3890/DELNP/2011BRPI0922466