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1. (WO2010079373) IMPROVED PHARMACEUTICAL FORMULATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079373 International Application No.: PCT/HU2010/000003
Publication Date: 15.07.2010 International Filing Date: 08.01.2010
Chapter 2 Demand Filed: 21.07.2010
IPC:
A61K 9/02 (2006.01) ,A61K 31/4164 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
02
Suppositories; Bougies; Bases for suppositories or bougies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
Applicants:
EGIS GYOGYSZERGYAR, Nyilvánosan, Müködö, Részvénytársaság [HU/HU]; Keresztúri út 30-38 H-1106 Budapest, HU (AllExceptUS)
MIKULASIK, Endre [HU/HU]; HU (UsOnly)
SZAKALY, Péter [HU/HU]; HU (UsOnly)
Inventors:
MIKULASIK, Endre; HU
SZAKALY, Péter; HU
Agent:
ADVOPATENT OFFICE OF PATENT AND TRADEMARK ATTORNEYS; P.O. Box 80 H-1255 Budapest, HU
Priority Data:
P 09 0001009.01.2009HU
P 10 0000607.01.2010HU
Title (EN) IMPROVED PHARMACEUTICAL FORMULATION
(FR) FORMULATION PHARMACEUTIQUE AMÉLIORÉE
Abstract:
(EN) The subject of the invention is a vaginal suppository with improved efficacy containing an antifungal active ingredient, wherein the said active ingredient is present simultaneously in dissolved and suspended form in the suppository base containing polyethylene-glycol and polysorbate. The ratio of the suspended and dissolved active ingredient in the suppository is reproducible and said ratio does not change during the storage. A further subject of the present invention is a process for manufacturing said pharmaceutical formulations.
(FR) La présente invention porte sur un suppositoire vaginal ayant une efficacité améliorée, contenant un principe actif antifongique, ledit principe actif étant présent simultanément sous une forme dissoute et une mise en suspension dans la base de suppositoire contenant du polyéthylène glycol et du polysorbate. Le rapport du principe actif mis en suspension et dissous dans le suppositoire est reproductible et ledit rapport ne change pas durant le stockage. La présente invention porte en outre sur un procédé de fabrication desdites formulations pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201109905EP2385821EA201190094