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1. (WO2010079343) FORMULATIONS OF VIABLE CELLS FOR ORAL DELIVERY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079343 International Application No.: PCT/GB2010/000035
Publication Date: 15.07.2010 International Filing Date: 11.01.2010
IPC:
A61K 9/20 (2006.01) ,A61K 35/74 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
Applicants:
CAMBRIDGE ENTERPRISE LIMITED [GB/GB]; The Old Schools Trinity Lane Cambridge CB2 1TN, GB (AllExceptUS)
RECIPHARMCOBRA HOLDINGS LTD. [GB/GB]; Stephenson Building Keele University Science Park Keele Staffordshire ST5 5SP, GB (AllExceptUS)
EDWARDS, Alexander [GB/GB]; GB (UsOnly)
SLATER, Nigel [GB/GB]; GB (UsOnly)
Inventors:
EDWARDS, Alexander; GB
SLATER, Nigel; GB
Agent:
MEWBURN ELLIS LLP; 33 Gutter Lane London EC2V 8AS, GB
Priority Data:
0900350.009.01.2009GB
Title (EN) FORMULATIONS OF VIABLE CELLS FOR ORAL DELIVERY
(FR) FORMULATIONS DE CELLULES VIABLES POUR UNE ADMINISTRATION ORALE
Abstract:
(EN) This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation significantly increases the survival of the cells in the intestinal tract and facilitates delivery of the viable cells to the intestine.
(FR) Cette invention porte sur des formulations solides pour l'administration orale de cellules microbiennes vivantes qui comprennent des cellules viables séchées et de petites quantités d'un agent de liaison à l'acide biliaire, par exemple, une résine échangeuse d'anions telle que la cholestyramine. La présence d'agents de liaison à l'acide biliaire dans la formulation augmente significativement la survie des cellules dans le tractus intestinal et facilite l'apport des cellules viables à l'intestin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2384190JP2012514629US20120027811CN102341100CN105663171AU2010204159
DK2384190IN3353/KOLNP/2011PT2384190