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1. (WO2010079340) METHODS FOR IDENTIFYING COMPOUNDS MODULATING TYPE-I TRANSMEBRANE MATRIX METALLOPROTEINASE (MMP)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079340 International Application No.: PCT/GB2010/000031
Publication Date: 15.07.2010 International Filing Date: 08.01.2010
IPC:
C12N 9/64 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
EISAI R & D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-8088, JP (AllExceptUS)
KLINE, Adam [GB/GB]; GB (UsOnly)
Inventors:
KLINE, Adam; GB
Agent:
HOLLYWOOD, Jane, Constance; Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ, GB
Priority Data:
0900261.908.01.2009GB
0900262.708.01.2009GB
Title (EN) METHODS FOR IDENTIFYING COMPOUNDS MODULATING TYPE-I TRANSMEBRANE MATRIX METALLOPROTEINASE (MMP)
(FR) DOSAGE
Abstract:
(EN) The invention relates to a method for identifying compounds that act as enhancers or inhibitors of matrix metalloproteinase (MMP) activity. The invention also relates to a method for diagnosing whether or not a subject is at risk of developing, or has, a disease associated with pathogenic APP processing. The invention further relates to the use of type I transmembrane protease inhibitors, in particular inhibitors of MMP 16, MMP 14 or MMP 15 activity, for preventing or treating diseases associated with pathogenic APP processing, such as Alzheimer's disease.
(FR) La présente invention concerne un procédé permettant d'identifier des composés renforçant ou inhibant l'activité métalloprotéase matricielle ou "MMP" (Matrix Metalloproteinase). L'invention concerne également un procédé permettant d'établir par avance si un sujet présente ou ne présente pas de risque de développer une maladie associée à une évolution d'APP pathogène, ou s'il en est déjà atteint. L'invention concerne en outre l'utilisation d'inhibiteurs de protéase transmembranaires de type I, en particuliers d'inhibiteurs de l'activité MMP 16, MMP 14 ou MMP 15, pour la prévention ou le traitement d'affections associées à une évolution d'APP pathogène, telle que la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)