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1. WO2010079340 - METHODS FOR IDENTIFYING COMPOUNDS MODULATING TYPE-I TRANSMEBRANE MATRIX METALLOPROTEINASE (MMP)

Publication Number WO/2010/079340
Publication Date 15.07.2010
International Application No. PCT/GB2010/000031
International Filing Date 08.01.2010
IPC
C12N 9/64 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
CPC
C12N 9/6491
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6489Metalloendopeptidases (3.4.24)
6491Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
Applicants
  • EISAI R & D MANAGEMENT CO., LTD. [JP]/[JP] (AllExceptUS)
  • KLINE, Adam [GB]/[GB] (UsOnly)
Inventors
  • KLINE, Adam
Agents
  • HOLLYWOOD, Jane, Constance
Priority Data
0900261.908.01.2009GB
0900262.708.01.2009GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR IDENTIFYING COMPOUNDS MODULATING TYPE-I TRANSMEBRANE MATRIX METALLOPROTEINASE (MMP)
(FR) DOSAGE
Abstract
(EN)
The invention relates to a method for identifying compounds that act as enhancers or inhibitors of matrix metalloproteinase (MMP) activity. The invention also relates to a method for diagnosing whether or not a subject is at risk of developing, or has, a disease associated with pathogenic APP processing. The invention further relates to the use of type I transmembrane protease inhibitors, in particular inhibitors of MMP 16, MMP 14 or MMP 15 activity, for preventing or treating diseases associated with pathogenic APP processing, such as Alzheimer's disease.
(FR)
La présente invention concerne un procédé permettant d'identifier des composés renforçant ou inhibant l'activité métalloprotéase matricielle ou "MMP" (Matrix Metalloproteinase). L'invention concerne également un procédé permettant d'établir par avance si un sujet présente ou ne présente pas de risque de développer une maladie associée à une évolution d'APP pathogène, ou s'il en est déjà atteint. L'invention concerne en outre l'utilisation d'inhibiteurs de protéase transmembranaires de type I, en particuliers d'inhibiteurs de l'activité MMP 16, MMP 14 ou MMP 15, pour la prévention ou le traitement d'affections associées à une évolution d'APP pathogène, telle que la maladie d'Alzheimer.
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