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1. (WO2010079255) USE OF INVERSE ANTAGONISTS AND/OR AGONISTS OF CB1 RECEPTORS FOR PREPARING DRUGS TO INCREASE MOTOR NEURONE EXCITABILITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079255 International Application No.: PCT/ES2010/070012
Publication Date: 15.07.2010 International Filing Date: 11.01.2010
Chapter 2 Demand Filed: 11.11.2010
IPC:
A61K 31/415 (2006.01) ,A61K 31/4155 (2006.01) ,A61K 31/4164 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/02 (2006.01) ,A61P 25/14 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4155
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
FUNDACIÓN DEL HOSPITAL NACIONAL DE PARAPLÉJICOS PARA LA INVESTIGACIÓN Y LA INTEGRACIÓN (FUHNPAIIN) [ES/ES]; Finca La Peraleda, s/n E-45004 Toledo, ES (AllExceptUS)
OLIVIERO, Antonio [IT/ES]; ES (UsOnly)
DE LOS REYES AGUILAR LEPE, Juan [ES/ES]; ES (UsOnly)
ROTONDI, Mario [IT/ES]; ES (UsOnly)
MOLINA HOLGADO, Eduardo [ES/ES]; ES (UsOnly)
CHIOVATO, Luca [IT/ES]; ES (UsOnly)
FOFFANI, Guglielmo [IT/ES]; ES (UsOnly)
MORDILLO MATEOS, Laura [ES/ES]; ES (UsOnly)
LOZANO SICILIA, Ángel [ES/ES]; ES (UsOnly)
GARCÍA OVEJERO, Daniel [ES/ES]; ES (UsOnly)
ARÉVALO MARTÍN, Ángel [ES/ES]; ES (UsOnly)
PÉREZ BORREGO, Yolanda [ES/ES]; ES (UsOnly)
Inventors:
OLIVIERO, Antonio; ES
DE LOS REYES AGUILAR LEPE, Juan; ES
ROTONDI, Mario; ES
MOLINA HOLGADO, Eduardo; ES
CHIOVATO, Luca; ES
FOFFANI, Guglielmo; ES
MORDILLO MATEOS, Laura; ES
LOZANO SICILIA, Ángel; ES
GARCÍA OVEJERO, Daniel; ES
ARÉVALO MARTÍN, Ángel; ES
PÉREZ BORREGO, Yolanda; ES
Agent:
PONS ARIÑO, Ángel; Glorieta de Rubén Darío, 4 E-28010 Madrid, ES
Priority Data:
PCT/ES2009/00001012.01.2009ES
Title (EN) USE OF INVERSE ANTAGONISTS AND/OR AGONISTS OF CB1 RECEPTORS FOR PREPARING DRUGS TO INCREASE MOTOR NEURONE EXCITABILITY
(ES) USO DE ANTAGONISTAS Y/O AGONISTAS INVERSOS DE LOS RECEPTORES CB1 PARA LA PREPARACIÓN DE MEDICAMENTOS QUE INCREMENTEN LA EXCITABILIDAD DE LAS MOTONEURONAS
(FR) UTILISATION D'ANTAGONISTES ET/OU D'AGONISTES INVERSES DES RÉCEPTEURS CB1 POUR LA PRÉPARATION DE MÉDICAMENTS QUI AUGMENTENT L'EXCITABILITÉ DES MOTONEURONES
Abstract:
(EN) Use of an inverse antagonist and/or agonist of CB1 receptors, preferably rimonabant, for preparing drugs that are useful for increasing motor neurone excitability at the level of the cerebral cortex and/or the brainstem and/or at the spinal level, and also a method for increasing motor neurone excitability by means of the administration of an inverse antagonist/agonist of CB1 receptors, and to the use of a pharmaceutical composition that comprises an inverse antagonist and/or agonist of CB1 receptors, preferably rimonabant, for increasing motor neurone excitability at the level of the cerebral cortex and/or the brainstem and/or at the spinal level.
(ES) Uso de un antagonista y/o agonista inverso de los receptores CB1, preferentemente rimonabant, para la preparación de medicamentos útiles para aumentar la excitabilidad de las neuronas motoras a nivel de la corteza cerebral y/o del tronco del encéfalo y/o a nivel espinal, así como a un método para aumentar la excitabilidad de las neuronas motoras a través de la administración de un antagonista/agonista inverso de los receptores CB1, y al uso de una composición farmacéutica que comprende un antagonista y/o agonista inverso de los receptores CB1, preferentemente rimonabant, para aumentar la excitabilidad de las neuronas motoras a nivel de la corteza cerebral y/o del tronco del encéfalo y/o a nivel espinal.
(FR) La présente invention concerne l'utilisation d'un antagoniste et/ou d'un agoniste inverse des récepteurs CB1, de préférence rimonabant, pour la préparation de médicaments utilisés pour augmenter l'excitabilité des motoneurones au niveau du cortex cérébral et/ou du tronc cérébral et/ou au niveau rachidien, ainsi qu'un procédé permettant d'augmenter l'excitabilité des motoneurones par le biais de l'administration d'un antagoniste/agoniste inverse des récepteurs CB1, et l'utilisation d'une composition pharmaceutique comprenant un antagoniste et/ou agoniste inverse des récepteurs CB1, de préférence rimonabant, pour augmenter l'excitabilité des motoneurones au niveau du cortex cérébral et/ou du tronc cérébral et/ou au niveau rachidien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)
Also published as:
EP2397137US20120015945