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1. (WO2010079253) BIO-MARKERS FOR DIAGNOSING FIBROSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079253 International Application No.: PCT/ES2010/070007
Publication Date: 15.07.2010 International Filing Date: 07.01.2010
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
PROYECTO DE BIOMEDICINA CIMA, S.L. [ES/ES]; C/ Etxesakan 28, Oficina 5 - Planta baja E-31180 Zizur Mayor - Navarra, ES (AllExceptUS)
CORRALES IZQUIERDO, Fernando José [ES/ES]; ES (UsOnly)
FERNÁNDEZ IRIGOYEN, Joaquín [ES/ES]; ES (UsOnly)
ODRIOZOLA MONCAYOLA, Leticia [ES/ES]; ES (UsOnly)
PRIETO VALTUEÑA, Jesús María [ES/ES]; ES (UsOnly)
SANTAMARÍA MARTÍNEZ, Enrique [ES/ES]; ES (UsOnly)
Inventors:
CORRALES IZQUIERDO, Fernando José; ES
FERNÁNDEZ IRIGOYEN, Joaquín; ES
ODRIOZOLA MONCAYOLA, Leticia; ES
PRIETO VALTUEÑA, Jesús María; ES
SANTAMARÍA MARTÍNEZ, Enrique; ES
Agent:
ARIAS SANZ, Juan; ABG Patentes, S.L. Avenidad de Burgos 16 D Edificio Euromor E-28036 Madrid, ES
Priority Data:
P20090005609.01.2009ES
Title (EN) BIO-MARKERS FOR DIAGNOSING FIBROSIS
(ES) BIOMARCADORES PARA EL DIAGNÓSTICO DE FIBROSIS
(FR) BIOMARQUEURS POUR LE DIAGNOSTIC DE LA FIBROSE
Abstract:
(EN) The invention relates to methods for detecting and diagnosing fibrosis and diseases associated with fibrosis, and to methods for determining the effectiveness of a therapy against fibrosis by determining the expression levels of bio-markers, where the one or more bio-markers are selected from the group formed by SLURP1, HAMP, GSN and APOD. The invention also relates to kits comprising reagents suitable for carrying out the methods according to the invention.
(ES) La invención se refiere a métodos para la detección y diagnóstico de fibrosis y enfermedades asociadas con fibrosis así como a métodos para la determinación de la eficacia de una terapia para fibrosis basado en la determinación de los niveles de expresión de dichos biomarcadores, en donde los biomarcadores son uno o más del grupo seleccionado de SLURP1, HAMP, GSN y APOD. La invención también se refiere a kits que comprenden reactivos adecuados para realizar los métodos de la invención.
(FR) L'invention concerne des méthodes pour la détection et le diagnostic de la fibrose et de maladies associées à la fibrose, ainsi que des méthodes destinées à déterminer l'efficacité d'un traitement contre la fibrose sur la base de la détermination des niveaux d'expression de biomarqueurs, ces biomarqueurs étant choisis parmi SLURPI, HAMP, GSN et/ou APOD. L'invention concerne également des trousses comprenant des réactifs appropriés pour la mise en oeuvre desdites méthodes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)