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1. (WO2010079241) USE OF ANTAGONISTS AND/OR INVERSE AGONISTS OF CB1 RECEPTORS FOR THE PREPARATION OF DRUGS THAT INCREASE MOTOR NEURON EXCITABILITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079241 International Application No.: PCT/ES2009/000010
Publication Date: 15.07.2010 International Filing Date: 12.01.2009
IPC:
A61K 31/00 (2006.01) ,A61K 31/415 (2006.01) ,A61P 25/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
FUNDACION HOSPITAL NACIONAL DE PARAPLEJICOS PARA LA INVESTIGACION Y LA INTEGRACION [ES/ES]; Finca la Peraleda, s/n E-45071 Toledo, ES (AllExceptUS)
OLIVIERO, Antonio [IT/IT]; IT (UsOnly)
AGUILAR LEPE, Juan de los Reyes [ES/ES]; ES (UsOnly)
ROTONDI, Mario [IT/IT]; IT (UsOnly)
CHIOVATO, Luca [IT/IT]; IT (UsOnly)
AREVALO MARTIN, Angel [ES/ES]; ES (UsOnly)
MOLINA HOLGADO, Eduardo [ES/ES]; ES (UsOnly)
GARCIA OVEJERO, Daniel [ES/ES]; ES (UsOnly)
MORDILLO MATEOS, Laura [ES/ES]; ES (UsOnly)
LOZANO SICILIA, Angel [ES/EC]; ES (UsOnly)
FOFFANI, Guglielmo [IT/IT]; ES (UsOnly)
PEREZ BORREGO, Yolanda [ES/ES]; ES (UsOnly)
Inventors:
OLIVIERO, Antonio; IT
AGUILAR LEPE, Juan de los Reyes; ES
ROTONDI, Mario; IT
CHIOVATO, Luca; IT
AREVALO MARTIN, Angel; ES
MOLINA HOLGADO, Eduardo; ES
GARCIA OVEJERO, Daniel; ES
MORDILLO MATEOS, Laura; ES
LOZANO SICILIA, Angel; ES
FOFFANI, Guglielmo; ES
PEREZ BORREGO, Yolanda; ES
Agent:
UNGRIA LOPEZ, Javier; Avenida Romón y Cajal, 78 E-28043 Madrid, ES
Priority Data:
Title (EN) USE OF ANTAGONISTS AND/OR INVERSE AGONISTS OF CB1 RECEPTORS FOR THE PREPARATION OF DRUGS THAT INCREASE MOTOR NEURON EXCITABILITY
(ES) USO DE ANTAGONISTAS Y/O AGONISTAS INVERSOS DE LOS RECEPTORES CB1 PARA LA PREPARACIÓN DE MEDICAMENTOS QUE INCREMENTEN LA EXCITABILIDAD DE LAS MOTONEURONAS
(FR) UTILISATION D'ANTAGONISTES ET/OU D'AGONISTES INVERSES DES RÉCEPTEURS CB1 POUR LA PRÉPARATION DE MÉDICAMENTS QUI AUGMENTENT L'EXCITABILITÉ DES MOTONEURONES
Abstract:
(EN) The invention relates to the use of an antagonist and/or inverse agonist of the CB1 receptors, preferably Rimonabant, for the preparation of drugs that can be used to increase motor neuron excitability in the cerebral cortex and/or the brain stem and/or the spinal cord, as well as to a method for increasing motor neuron excitability by administering an antagonist/inverse agonist of the CB1 receptors, and to the use of a pharmaceutical composition that contains an antagonist and/or inverse agonist of the CB1 receptors, preferably Rimonabant, to increase motor neuron excitability in the cerebral cortex and/or the brain stem and/or the spinal cord.
(ES) La invención se refiere al uso de un antagonista y/o agonista inverso de los receptores CBl, preferentemente Riraonabant, para la preparación de medicamentos útiles para aumentar la excitabilidad de las neuronas motoras a nivel de la corteza cerebral y/o del tronco del encéfalo y/o a nivel espinal, así como a un método para aumentar la excitabilidad de las neuronas motoras a través de la administración de un antagonista/agonista inverso de los receptores CBl, y al uso de una composición farmacéutica que comprende un antagonista y/o agonista inverso de los receptores CBl, preferentemente Rimonabant, para aumentar la excitabilidad de las neuronas motoras a nivel de la corteza cerebral y/o del tronco del encéfalo y/o a nivel espinal.
(FR) La présente invention concerne l'utilisation d'un antagoniste et/ou d'un agoniste inverse des récepteurs CB1, de préférence Rimonabant, pour la préparation de médicaments utilisés pour augmenter l'excitabilité des motoneurones au niveau du cortex cérébral et/ou du tronc cérébral et/ou au niveau rachidien, ainsi qu'un procédé permettant d'augmenter l'excitabilité des motoneurones par le biais de l'administration d'un antagoniste/agoniste inverse des récepteurs CB1, et l'utilisation d'une composition pharmaceutique comprenant un antagoniste et/ou agoniste inverse des récepteurs CB1, de préférence Rimonabant, pour augmenter l'excitabilité des motoneurones au niveau du cortex cérébral et/ou du tronc cérébral et/ou au niveau rachidien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)