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1. WO2010079079 - PDGF-Rβ BINDERS

Publication Number WO/2010/079079
Publication Date 15.07.2010
International Application No. PCT/EP2009/067447
International Filing Date 17.12.2009
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
14
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
A61K 49/14 (2006.01)
A61K 51/08 (2006.01)
CPC
A61K 49/085
A61K 49/14
A61K 51/08
A61K 51/088
A61K 51/1027
C07K 2319/00
Applicants
  • GENERAL ELECTRIC COMPANY [US/US]; 1 River Road Schenectady, New York 12345, US (AllExceptUS)
  • MARINO, Michael Ernest [US/US]; US (UsOnly)
  • SYUD, Faisal Ahmed [US/US]; US (UsOnly)
  • SCHAFFER, Paul [CA/CA]; CA (UsOnly)
  • LEE, Brian Duh-Lan [US/US]; US (UsOnly)
  • ZHANG, Rong [CN/US]; US (UsOnly)
  • LINDBORG, Malin [SE/SE]; SE (UsOnly)
  • GUNNERIUSSON, Elin [SE/SE]; SE (UsOnly)
  • LENDEL, Christofer [SE/SE]; SE (UsOnly)
Inventors
  • MARINO, Michael Ernest; US
  • SYUD, Faisal Ahmed; US
  • SCHAFFER, Paul; CA
  • LEE, Brian Duh-Lan; US
  • ZHANG, Rong; US
  • LINDBORG, Malin; SE
  • GUNNERIUSSON, Elin; SE
  • LENDEL, Christofer; SE
Agents
  • CANNING, Lewis Reuben; GE Healthcare Limited Pollards Wood Nightingales Lane Chalfont St Giles Buckinghamshire HP8 4SP, GB
Priority Data
12/336,78017.12.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PDGF-Rβ BINDERS
(FR) AGENTS SE LIANT AU PDGF-RΒ
Abstract
(EN)
Provided herein are PDGF-Rβ imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-β. Also provided are in vivo imaging methods using the imaging agents.
(FR)
Cette invention concerne des agents d'imagerie PDGF-Rβ qui sont des polypeptides marqués avec un générateur de signal (par exemple marqueur paramagnétique, isotope ou fluorophore), lesdits agents d'imagerie se liant spécifiquement au PDGF-Rβ. L'invention décrit également des procédés d'imagerie in vivo utilisant lesdits agents d'imagerie.
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