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1. (WO2010079068) IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/079068 International Application No.: PCT/EP2009/067341
Publication Date: 15.07.2010 International Filing Date: 16.12.2009
Chapter 2 Demand Filed: 06.10.2010
IPC:
C12N 9/04 (2006.01) ,C12P 7/02 (2006.01) ,C12P 7/22 (2006.01) ,C12P 7/26 (2006.01) ,C12P 17/00 (2006.01) ,C12P 17/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
04
acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
22
aromatic
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
24
containing a carbonyl group
26
Ketones
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
02
Oxygen as only ring hetero atoms
04
containing a five-membered hetero ring, e.g. griseofulvin
Applicants:
BASF SE [DE/DE]; 67056 Ludwigshafen, DE (AllExceptUS)
SCHNEIDER, Nina [DE/DE]; DE (UsOnly)
HÖFFKEN, Wolfgang [DE/DE]; DE (UsOnly)
Inventors:
SCHNEIDER, Nina; DE
HÖFFKEN, Wolfgang; DE
Agent:
SCHWEIGER, Georg; Reitstötter Kinzebach Sternwartstr. 4 81679 München, DE
Priority Data:
08172003.917.12.2008EP
Title (DE) VERBESSERTE BIOKATALYSATOREN ZUR HERSTELLUNG VON DULOXETINALKOHOL
(EN) IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
(FR) BIOCATALYSEURS AMÉLIORÉS POUR LA FABRICATION D'ALCOOL DE DULOXÉTINE
Abstract:
(DE) Die vorliegende Erfindung betrifft neuartige Phenylethanol-Dehydrogenase-Mutanten, Verfahren zu deren Herstellung; dafür kodierende Nukleinsäuresequenzen, Expressionskassetten, Vektoren und rekombinante Mikroorganismen, welche diese Sequenzen enthalten; Verfahren zur biokatalytischen Synthese von substituierten, optisch aktiven Alkoholen unter Verwendung dieser Mutanten; sowie insbesondere ein Verfahren zur Herstellung von Duloxetinalkohol bzw. Duloxetin, umfassend einen von diesen Mutanten katalysierten biokatalytischen Syntheseschritt.
(EN) The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
(FR) La présente invention porte sur des mutants de phényléthanol déshydrogénase d'un nouveau type, sur un procédé permettant de les fabriquer, sur des séquences d'acides nucléiques codant pour ceux-ci, des cassettes d'expression, des vecteurs et des microorganismes recombinants, lesquels contiennent ces séquences; sur un procédé de synthèse biocatalytique d'alcools substitués, optiquement actifs, par utilisation de ces mutants; et en particulier sur un procédé de fabrication d'alcool de duloxétine ou de duloxétine, comportant une étape de synthèse biocatalytique catalysée par ces mutants.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
IL213599EP2379714JP2012511922US20110250655CN102317450CA2747058
MX2011006464IN4605/CHENP/2011