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1. WO2010078916 - IMMUNOCYTOKINES FOR TUMOUR THERAPY WITH CHEMOTHERAPEUTIC AGENTS

Publication Number WO/2010/078916
Publication Date 15.07.2010
International Application No. PCT/EP2009/008920
International Filing Date 14.12.2009
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4188
condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
20
Interleukins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A61K 45/06 (2006.01)
A61K 31/4188 (2006.01)
A61K 38/20 (2006.01)
A61K 47/48 (2006.01)
A61P 35/00 (2006.01)
CPC
A61K 31/495
A61K 38/2013
A61K 45/06
A61K 47/6813
A61K 47/6865
Applicants
  • PHILOGEN S.P.A. [IT/IT]; La Lizza 7 I-53100 Siena, IT (AllExceptUS)
  • PEDRETTI, Marta [IT/CH]; CH (UsOnly)
  • NERI, Dario [IT/CH]; CH (UsOnly)
Inventors
  • PEDRETTI, Marta; CH
  • NERI, Dario; CH
Agents
  • KING, Hilary; Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS, GB
Priority Data
61/139,48419.12.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOCYTOKINES FOR TUMOUR THERAPY WITH CHEMOTHERAPEUTIC AGENTS
(FR) IMMUNOCYTOKINES POUR THÉRAPIE TUMORALE AVEC AGENTS CHIMIOTHÉRAPIQUES
Abstract
(EN)
lmmunocytokine comprising cytokine, e.g. interleukin 2 (IL-2), conjugated to antibody against tumour neovasculature antigen, e.g. tenascin-C, for use in combination therapy with chemotherapeutic agent such as temozolomide. Use of immunocytokine and chemotherapy for treatment of tumours e.g. glioblastoma and other cancers.
(FR)
L'invention porte sur une immunocytokine qui comporte une cytokine, par exemple l'interleukine 2 (IL-2), conjuguée à un anticorps dirigé contre un antigène de néo-vascularisation tumorale, par exemple la ténascine-C, pour une utilisation dans une thérapie de combinaison avec un agent chimiothérapique tel que le témozolomide. L'invention porte également sur une utilisation de l'immunocytokine et sur une chimiothérapie pour le traitement de tumeurs, par exemple un glioblastome et d'autres cancers.
Also published as
Latest bibliographic data on file with the International Bureau