Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010078905) BENZOTHIAZOLONE DERIVATIVE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078905 International Application No.: PCT/EP2009/008756
Publication Date: 15.07.2010 International Filing Date: 08.12.2009
IPC:
C07D 277/68 (2006.01) ,C07D 417/10 (2006.01) ,C07D 417/14 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60
condensed with carbocyclic rings or ring systems
62
Benzothiazoles
68
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE (AllExceptUS)
STIEBER, Frank [DE/DE]; DE (UsOnly)
SCHADT, Oliver [DE/DE]; DE (UsOnly)
DORSCH, Dieter [DE/DE]; DE (UsOnly)
BLAUKAT, Andree [DE/DE]; DE (UsOnly)
Inventors:
STIEBER, Frank; DE
SCHADT, Oliver; DE
DORSCH, Dieter; DE
BLAUKAT, Andree; DE
Priority Data:
10 2009 003 975.907.01.2009DE
Title (DE) BENZOTHIAZOLONDERIVATE
(EN) BENZOTHIAZOLONE DERIVATIVE
(FR) DÉRIVÉS DE LA BENZOTHIAZOLONE
Abstract:
(DE) Verbindungen der Formel I worin R1, R2, R3, R3', R4, R4', E, E', E" und E"' die in Anspruch 1 angegebenen Bedeutungen haben, sind Inhibitoren der Tyrosinkinasen, insbesondere der Met-Kinase und können u.a. zur Behandlung von Tumoren eingesetzt werden.
(EN) The invention relates to compounds of the formula I, where R1, R2, R3, R3', R4, R4', E, E', E" and E"' have the meanings given in claim 1, being inhibitors of tyrosine kinases, in particular met kinase, and can be used for treating tumors, among other uses.
(FR) Composés de formule (I) dans laquelle R1, R2, R3, R3', R4, R4', E, E', E'' et E"', qui ont les significations indiquées dans la revendication 1, sont des inhibiteurs des tyrosine kinases, notamment de la kinase Met et peuvent être utilisés entre autres pour le traitement de tumeurs.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
AR074989IL213827MXMX/a/2011/007232EP2373635SG172424JP2012514610
US20110269756CN102272112CA2748908EA201101042MX2011007232KR1020110102504
BRPI0923602AU2009336847IN3312/KOLNP/2011