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1. (WO2010078526) ANTI-LYMPHOTOXIN ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/078526 International Application No.: PCT/US2009/069967
Publication Date: 08.07.2010 International Filing Date: 31.12.2009
IPC:
C07K 16/24 (2006.01) ,A61P 37/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
RANGER, Ann, M. [US/US]; US (UsOnly)
GARBER, Ellen [US/US]; US (UsOnly)
LUGOVSKOY, Alexey, Alexandrovich [US/US]; US (UsOnly)
ARNDT, Joseph [US/US]; US (UsOnly)
CARAVELLA, Justin A. [US/US]; US (UsOnly)
TAYLOR, Frederick, R. [US/US]; US (UsOnly)
ANTOGNETTI, Giovanna [US/US]; US (UsOnly)
DAY, Eric [US/US]; US (UsOnly)
BIOGEN IDEC MA INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
Inventors:
RANGER, Ann, M.; US
GARBER, Ellen; US
LUGOVSKOY, Alexey, Alexandrovich; US
ARNDT, Joseph; US
CARAVELLA, Justin A.; US
TAYLOR, Frederick, R.; US
ANTOGNETTI, Giovanna; US
DAY, Eric; US
Agent:
WILLIAMS, Megan E.; Lahive & Cockfield, LP One Post Office Square Boston, MA 02109-2127, US
Priority Data:
61/142,18231.12.2008US
Title (EN) ANTI-LYMPHOTOXIN ANTIBODIES
(FR) ANTICORPS ANTI-LYMPHOTOXINE
Abstract:
(EN) The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LTβR signaling are also provided.
(FR) La présente invention est basée, au moins en partie, sur l'identification d'une nouvelle classe d'anticorps qui conduisent, par exemple, à des capacités améliorées de blocage des LT. L'invention porte également sur des procédés de production des molécules de liaison en objet et sur des procédés d'utilisation des molécules de liaison de l'invention pour antagoniser la signalisation LTβR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)