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1. (WO2010078430) SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078430 International Application No.: PCT/US2009/069825
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61K 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
Applicants:
ARQULE, INC. [US/US]; 19 Presidential Way Woburn, MA 01801, US (AllExceptUS)
HILL, Jason [GB/US]; US (UsOnly)
ALI, Syed, M. [IN/US]; US (UsOnly)
ASHWELL, Mark [GB/US]; US (UsOnly)
TANDON, Manish [US/US]; US (UsOnly)
LAPIERRE, Jean-Marc [US/US]; US (UsOnly)
NAMDEV, Nivedita [US/US]; US (UsOnly)
NICEWONGER, Robert [US/US]; US (UsOnly)
MOUSSA, Magdi [US/US]; US (UsOnly)
YANG, Rui-Yang [US/US]; US (UsOnly)
Inventors:
HILL, Jason; US
ALI, Syed, M.; US
ASHWELL, Mark; US
TANDON, Manish; US
LAPIERRE, Jean-Marc; US
NAMDEV, Nivedita; US
NICEWONGER, Robert; US
MOUSSA, Magdi; US
YANG, Rui-Yang; US
Agent:
ELRIFI, Ivor, R.; Mintz, Levin, Cohn, Ferris, Glovsky and Popeo PC One Financial Center Boston, MA 02111, US
Priority Data:
61/141,40630.12.2008US
Title (EN) SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS
(FR) COMPOSÉS DE 1H-PYRAZOLO-[3,4-D]PYRIMIDINE-6-AMINES SUBSTITUÉES
Abstract:
(EN) The present invention relates to substituted 1H-pyrazoIo-[3,4-d]pyrimidine-6-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
(FR) La présente invention porte sur des composés de 1H-pyrazolo-[3,4-d]pyrimidine-6-amines substituées et sur des procédés de synthèse de ces composés. La présente invention porte également sur des compositions pharmaceutiques contenant des composés de 1H-pyrazolo-[3,4-d]pyrimidine-6-amines substituées et sur des méthodes de traitement de troubles de la prolifération cellulaire, tels que le cancer, par l'administration de ces composés et de ces compositions pharmaceutiques à des sujets en ayant besoin.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379556CA2748174AU2009335019