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1. (WO2010078427) SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078427 International Application No.: PCT/US2009/069821
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
C07D 471/04 (2006.01) ,C07D 471/14 (2006.01) ,C07D 487/04 (2006.01) ,C07D 495/14 (2006.01) ,A61K 31/437 (2006.01) ,A61P 35/00 (2006.01) ,C07D 493/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
ARQULE, INC. [US/US]; 19 Presidential Way Woburn, MA 01801, US (AllExceptUS)
TANDON, Manish [US/US]; US (UsOnly)
ALI, Syed, M. [IN/US]; US (UsOnly)
ASHWELL, Mark [GB/US]; US (UsOnly)
WANG, Jianqiang [US/US]; US (UsOnly)
NAMDEV, Nivedita [US/US]; US (UsOnly)
HILL, Jason [GB/US]; US (UsOnly)
WESTLUND, Neil [US/US]; US (UsOnly)
DALTON, Audra [US/US]; US (UsOnly)
BRASSARD, Chris [US/US]; US (UsOnly)
FILIKOV, Anton [US/US]; US (UsOnly)
PALMA, Rocio [US/US]; US (UsOnly)
VENSEL, David [US/US]; US (UsOnly)
Inventors:
TANDON, Manish; US
ALI, Syed, M.; US
ASHWELL, Mark; US
WANG, Jianqiang; US
NAMDEV, Nivedita; US
HILL, Jason; US
WESTLUND, Neil; US
DALTON, Audra; US
BRASSARD, Chris; US
FILIKOV, Anton; US
PALMA, Rocio; US
VENSEL, David; US
Agent:
PAVAO, Matthew; Mintz, Levin, Cohn, Ferris, Glovsky & Popeo PC One Financial Center Boston, MA 02111, US
Priority Data:
61/141,37130.12.2008US
Title (EN) SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS
(FR) COMPOSÉS DE PYRAZOLO[3,4-B]PYRIDINE SUBSTITUÉS
Abstract:
(EN) The present invention relates to substituted imidazoly 1-5,6- dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
(FR) La présente invention concerne des composés d'imidazolyl-5,6-dihydrobenzo[n]isoquinoléine substitués et des procédés de synthèse de ces composés. La présente invention concerne en outre des compositions pharmaceutiques contenant des composés d'imidazolyl-5,6-dihydrobenzo[n]isoquinoléine substitués et des procédés de traitement de troubles de prolifération cellulaire, tels que le cancer, par administration de ces composés et compositions pharmaceutiques à des sujets nécessitant ceci.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379551CA2748276AU2009335016