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1. (WO2010078421) SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078421 International Application No.: PCT/US2009/069813
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
C07D 221/10 (2006.01) ,C07D 401/12 (2006.01) ,C07D 471/10 (2006.01) ,A61K 31/55 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
221
Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02
condensed with carbocyclic rings or ring systems
04
Ortho- or peri-condensed ring systems
06
Ring systems of three rings
10
Aza-phenanthrenes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ARQULE, INC. [US/US]; 19 Presidential Way Woburn, MA 01801, US (AllExceptUS)
ALI, Syed, M. [IN/US]; US (UsOnly)
ASHWELL, Mark [GB/US]; US (UsOnly)
TANDON, Manish [US/US]; US (UsOnly)
YANG, Rui-yang [US/US]; US (UsOnly)
LIU, Yanbin [CN/US]; US (UsOnly)
VENSEL, David [US/US]; US (UsOnly)
EATHIRAJ, Sudharshan [IN/US]; US (UsOnly)
PALMA, Rocio [US/US]; US (UsOnly)
LAPIERRE, Jean-marc [US/US]; US (UsOnly)
WESTLUND, Neil [US/US]; US (UsOnly)
WU, Hui [CN/US]; US (UsOnly)
NAMDEV, Nivedita [US/US]; US (UsOnly)
KELLEHER, Eugene [US/US]; US (UsOnly)
Inventors:
ALI, Syed, M.; US
ASHWELL, Mark; US
TANDON, Manish; US
YANG, Rui-yang; US
LIU, Yanbin; US
VENSEL, David; US
EATHIRAJ, Sudharshan; US
PALMA, Rocio; US
LAPIERRE, Jean-marc; US
WESTLUND, Neil; US
WU, Hui; US
NAMDEV, Nivedita; US
KELLEHER, Eugene; US
Agent:
ELRIFI, Ivor, R.; Mintz, Levin, Cohn, Ferris Glovsky & Popeo PC One Financial Center Boston, MA 02111, US
Priority Data:
61/141,43930.12.2008US
61/260,50512.11.2009US
Title (EN) SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS
(FR) COMPOSÉS DE 5,6-DIHYDRO-6-PHÉNYLBENZO[F]ISOQUINOLÉINE-2-AMINES SUBSTITUÉES
Abstract:
(EN) The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
(FR) La présente invention porte sur des composés de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amines substituées et sur des procédés de synthèse de ces composés. La présente invention porte également sur des compositions pharmaceutiques contenant des composés de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amines substituées et sur des méthodes de traitement de troubles de la prolifération cellulaire, tels que le cancer, par l'administration de ces composés et de ces compositions pharmaceutiques à des sujets en ayant besoin.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL213787EP2379506JP2012514045CN102325755CA2748491KR1020110099790
ES2554623BRPI0923786DK2379506AU2009335010IN2700/KOLNP/2011