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1. (WO2010078403) METHODS AND COMPOSITIONS FOR DIAGNOSING UROLOGICAL DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078403 International Application No.: PCT/US2009/069784
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
LIPELLA PHARMACEUTICALS INC. [US/US]; 5414 Guarino Road Pittsburgh, PA 15217, US (AllExceptUS)
CHANCELLOR, Michael, B. [US/US]; US (UsOnly)
KUO, Hann-Chorng; TW (UsOnly)
Inventors:
CHANCELLOR, Michael, B.; US
KUO, Hann-Chorng; TW
Agent:
PABST, Patrea, L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E. Suite 320 Atlanta, GA 30309, US
Priority Data:
61/141,51430.12.2008US
Title (EN) METHODS AND COMPOSITIONS FOR DIAGNOSING UROLOGICAL DISORDERS
(FR) MÉTHODES ET COMPOSITIONS POUR DIAGNOSTIQUER DES TROUBLES UROLOGIQUES
Abstract:
(EN) It has been discovered that cytokines, chemokines, and growth factors in urine are biomarkers indicative of urological disorders including interstitial cystitis/painful bladder syndrome and overactive bladder syndrome. Preferred chemokine biomarkers are CCL2, CCL4 (MIP-1β), CCL11, CXCL1 (GRO-α), sCD40L, IL-12p70/p40, IL-5. sIL-2Rα, IL-6, IL- 10, IL-8, and EGF. The concentration of one or more of these chemokines in an urine sample can be used to assist in the diagnosis of urological disorders. Methods for evaluating the effectiveness of treatments for urological disorders and for assessing the severity of urological disorders are also provided.
(FR) Selon l'invention, il a été découvert que les cytokines, chimiokines et facteurs de croissance dans l'urine sont des biomarqueurs indicatifs de troubles urologiques comprenant la cystite interstitielle/le syndrome de la vessie douloureuse et le syndrome de la vessie suractive. Les biomarqueurs de chimiokine préférés sont CCL2, CCL4 (MIP-1β), CCL11, CXCL1 (GRO-α), sCD40L, IL-12p70/p40, IL-5. sIL-2Rα, IL-6, IL- 10, IL-8 et EGF. La concentration de l'une ou de plusieurs de ces chimiokines dans un échantillon d'urine peut être utilisée pour favoriser le diagnostic de troubles urologiques. L'invention porte également sur des méthodes d'évaluation de l'efficacité de traitements pour des troubles urologiques et des méthodes d'évaluation de la gravité des troubles urologiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)