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1. (WO2010078229) ANTI-VIRAL COMPOUNDS, TREATMENT, AND ASSAY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078229 International Application No.: PCT/US2009/069556
Publication Date: 08.07.2010 International Filing Date: 28.12.2009
IPC:
A61K 31/505 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Applicants:
SOUTHERN RESEARCH INSTITUTE [US/US]; Office Of Commercialization and Intellectual Property 2000 9th Avenue South P.O. Box 55305 Birmingham, AL 35205-5305, US (AllExceptUS)
MADDRY, Joseph, A. [US/US]; US (UsOnly)
SEVERSON, William [US/US]; US (UsOnly)
JONSSON, Colleen, B. [US/US]; US (UsOnly)
NOAH, James, W. [US/US]; US (UsOnly)
NOAH, Diana, L. [US/US]; US (UsOnly)
CHEN, Xi [CN/US]; US (UsOnly)
Inventors:
MADDRY, Joseph, A.; US
SEVERSON, William; US
JONSSON, Colleen, B.; US
NOAH, James, W.; US
NOAH, Diana, L.; US
CHEN, Xi; US
Agent:
BALLS, R, James; Connolly Bove Lodge & Hutz LLP 1875 Eye Street, NW Suite 1100 Washington, DC 20006, US
Priority Data:
61/141,16129.12.2008US
Title (EN) ANTI-VIRAL COMPOUNDS, TREATMENT, AND ASSAY
(FR) COMPOSÉS ANTIVIRAUX, TRAITEMENT ET DOSAGE
Abstract:
(EN) The compounds provided herein are suitable for inhibiting a virus in a patient and for treating a patient suffering from a viral infection such as an influenza virus. Also provided is a method for screening of compounds for use in treating and preventing viral infections. The assay screens compounds for activity against an influenza virus by measuring the cytopathogenic effect (CPE) of the compound on influenza infected-cells using precent cell viability as the end point.
(FR) L'invention porte sur des composés appropriés à inhiber un virus chez un patient et à traiter un patient souffrant d'une infection virale telle qu'un virus de la grippe. L'invention porte également sur un procédé de criblage de composés destinés à être utilisés pour le traitement et la prévention des infections virales. Le dosage crible des composés pour déterminer une activité contre un virus de la grippe par mesure de l'effet cytopathogène (CPE) du composé sur les cellules infectées par la grippe à l'aide d'une viabilité cellulaire en pourcentage en tant que critère d'évaluation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2381944US20120040966CN102307580CA2748719EA201190069MX2011007130
KR1020110130393IN2859/KOLNP/2011BRPI0923796