Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010078045) METHOD OF MAKING SMALL LIPOSOMES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078045 International Application No.: PCT/US2009/068499
Publication Date: 08.07.2010 International Filing Date: 17.12.2009
IPC:
A61K 9/127 (2006.01) ,C07K 14/775 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
775
Apolipopeptides
Applicants:
ONCOTHYREON, INC. [US/US]; 2601 Fourth Avenue Suite 500 Seattle, Washington 98121, US (AllExceptUS)
DUPUIT, Robert, A. [CA/CA]; CA (UsOnly)
REILLEY, William, J. [US/US]; US (UsOnly)
Inventors:
DUPUIT, Robert, A.; CA
REILLEY, William, J.; US
Agent:
HOSTETLER, Michael, J.; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050, US
Priority Data:
61/138,35317.12.2008US
Title (EN) METHOD OF MAKING SMALL LIPOSOMES
(FR) PROCÉDÉ DE FABRICATION DE PETITS LIPOSOMES
Abstract:
(EN) Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.
(FR) La présente invention concerne des liposomes ayant une taille de particules restreinte qui sont préparés par mélange sensiblement continu de courants d'eau à écoulement sensiblement continu, et d'un solvant organique, qui contiennent un (des) lipide(s) capable(s) de former des liposomes, et par refroidissement du mélange pour que des liposomes se forment, le rapport de la vitesse d'écoulement du courant d'eau sur la vitesse d'écoulement du courant de solvant organique, et la vitesse de refroidissement dudit mélange, étant maîtrisés de manière à obtenir une préparation de liposomes telle qu'au moins environ 90 % des liposomes ont une taille de particules inférieure à environ 200 nm.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2367532SG172257JP2012512260US20120034294CN102256595CA2747182
EA201100829JP2014224127MX2011006562KR1020110094114CN105935352AU2009333177
AU2013273711IN2997/KOLNP/2011BRPI0923001