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1. (WO2010078042) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078042 International Application No.: PCT/US2009/068492
Publication Date: 08.07.2010 International Filing Date: 17.12.2009
IPC:
A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
CDG THERAPEUTICS, INC. [US/US]; 1917 Baltimore Drive Elk Grove, IL 60007, US (AllExceptUS)
DAS GUPTA, Tapas [US/US]; US (UsOnly)
MEHTA, Rajendra, G. [US/US]; US (UsOnly)
MEHTA, Rajeshwari [US/US]; US (UsOnly)
BEATTIE, Craig [US/US]; US (UsOnly)
Inventors:
DAS GUPTA, Tapas; US
MEHTA, Rajendra, G.; US
MEHTA, Rajeshwari; US
BEATTIE, Craig; US
Agent:
PELTO, Don; Sheppard Mullin Richter & Hampton LLC 11th Floor East 1300 I Street NW Washington, DC 20005, US
Priority Data:
12/337,16717.12.2008US
Title (EN) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS
(FR) COMPOSITIONS ET PROCÉDÉS POUR LA PRÉVENTION DU CANCER AVEC DES CUPRÉDOXINES
Abstract:
(EN) The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The at least one other chemopreventive agent may comprise an antiestrogen such as Tamoxifen. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
(FR) La présente invention concerne des compositions et des procédés qui comprennent des agents chimiopréventifs qui peuvent être une ou plusieurs cuprédoxines ou des variantes, des dérivés et des équivalents structuraux de cuprédoxines, et au moins un autre agent chimiopréventif. Ces compositions peuvent notamment comprendre de l'azurine de Pseudomonas aeruginosa et/ou la région du résidu 50-77 de l'azurine (p28). Le ou les autres agents chimiopréventifs peuvent comprendre un anti-estrogène tel que le Tamoxifène. Les compositions de l'invention peuvent être utilisées pour prévenir le développement de lésions prémalignes dans des cellules, des tissus et des animaux mammaliens, et ainsi prévenir le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL213657SG172195EP2379097JP2012512259CN102316887CA2747404
KR1020110126595AU2009333174IN5232/DELNP/2011