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1. (WO2010078025) MODIFIED PYRAZINE DERIVATIVES AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/078025 International Application No.: PCT/US2009/068453
Publication Date: 08.07.2010 International Filing Date: 17.12.2009
IPC:
C07D 241/26 (2006.01) ,A61K 41/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
241
Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02
not condensed with other rings
10
having three double bonds between ring members or between ring members and non-ring members
14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
26
with nitrogen atoms directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
Applicants:
MALLINCKRODT INC. [US/US]; 675 McDonnell Boulevard Hazelwood, MO 63042, US (AllExceptUS)
POREDDY, Amruta [US/US]; US (UsOnly)
NEUMANN, William, L. [US/US]; US (UsOnly)
Inventors:
POREDDY, Amruta; US
NEUMANN, William, L.; US
Agent:
SEURER, Jerad, G.; Mallinckrodt Inc. 675 McDonnell Boulevard Hazelwood, MO 63042, US
Priority Data:
61/138,14917.12.2008US
61/139,91122.12.2008US
Title (EN) MODIFIED PYRAZINE DERIVATIVES AND USES THEREOF
(FR) DÉRIVÉS MODIFIÉS DE PYRAZINE ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein are excretable by the renal system of a subject or patient and are useful for visualizing the renal system of a subject or patient. Upon excitation by electromagnetic radiation, a number of the compounds disclosed herein exhibit luminescence and are externally detectable when present in the body fluid of a patient or subject. Also provided herein are methods for visualizing the renal system of a subject or patient.
(FR) La présente invention concerne des composés, des préparations, et des formulations, comprenant des dérivés de pyrazine comportant plusieurs substituants contenant du polyéthylène glycol. L'invention propose ainsi de nombreux composés qui permettent de visualiser le système rénal d'un sujet ou patient, et qui sont excrétables par son système rénal. Lorsqu'ils sont excités par un rayonnement électromagnétique, un certain nombre de composés de l'invention font preuve de luminescence et sont détectables depuis l'extérieur quand ils sont présents dans le liquide organique d'un patient ou sujet. L'invention concerne également des procédés permettant de visualiser le système rénal d'un sujet ou patient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2376459JP2012512256US20110250139CA2747454DK2376459