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1. (WO2010077741) DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077741 International Application No.: PCT/US2009/067336
Publication Date: 08.07.2010 International Filing Date: 09.12.2009
IPC:
A61K 31/33 (2006.01) ,G01N 33/92 (2006.01) ,A61P 13/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92
involving lipids, e.g. cholesterol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street and Broadway New York, New York 10027, US (AllExceptUS)
LEE, Thomas, H. [KR/US]; US (UsOnly)
KIM, Mihwa [KR/US]; US (UsOnly)
Inventors:
LEE, Thomas, H.; US
KIM, Mihwa; US
Agent:
HALEY, James, F, JR.; Ropes & Gray LLP 1211 Avenue of Americas New York, New York 10036, US
Priority Data:
61/201,35409.12.2008US
Title (EN) DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE
(FR) DIAGNOSTIC ET THÉRAPIE D'UN DYSFONCTIONNEMENT D'ORGANE À L'AIDE DE SPHINGANINE-1-PHOSPHATE
Abstract:
(EN) The invention relates to the treatment and diagnosis of organ dysfunction caused by ischemia reperfusion injury. In particular, the invention relates to sphinganine-1-phosphate, a sphingolipid metabolite, and its use in the diagnosing, preventing, and/or treating ischemia reperfusion-associated disorders, including, without limitation, disorders of the kidney, liver, lung, brain, and heart.
(FR) L'invention porte sur le traitement et le diagnostic d'un dysfonctionnement d'organe provoqué par une blessure par reperfusion ischémique. En particulier, l'invention porte sur le sphinganine-1-phosphate, un métabolite sphingolipidique, et sur son utilisation dans le diagnostic, la prévention et/ou le traitement de troubles associés à une reperfusion ischémique, comprenant, sans y être limité, des troubles des reins, du foie, des poumons, du cerveau et du cœur.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20110294874