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1. (WO2010077693) METHOD FOR IDENTIFYING AGENTS FOR INHIBITING CELL MOTILITY AND INVASIVENESS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077693 International Application No.: PCT/US2009/067220
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
A61K 38/16 (2006.01) ,A61P 9/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnet Avenue, ML 7032 Cincinnati, Ohio 45229-3039, US (AllExceptUS)
HEGDE, Rashmi [US/US]; US (UsOnly)
Inventors:
HEGDE, Rashmi; US
Agent:
KLINE, Gregory, H.; Davis Wright Tremaine, LLP 505 Montgomery Street, Suite 800 San Francisco, California 94111, US
Priority Data:
61/120,56408.12.2008US
Title (EN) METHOD FOR IDENTIFYING AGENTS FOR INHIBITING CELL MOTILITY AND INVASIVENESS
(FR) PROCÉDÉ D'IDENTIFICATION D'AGENTS D'INHIBITION DE LA MOTILITÉ CELLULAIRE ET DE LA CAPACITÉ D'INVASION CELLULAIRE
Abstract:
(EN) The present invention provides a novel mechanistic pathway and methods related to this pathway for the identification of compounds for the treatment of diseases involving cell proliferation, invasion and/or metastasis such as cancer. In particular, the instant invention relates to the phosphatase activity of Eya and the Eya-Six complex as a target for identifying novel therapeutic agents for the treatment of proliferative, invasive and/or metastatic disorders, and compositions identified using the methods disclosed herein.
(FR) La présente invention porte sur une nouvelle voie mécanistique et sur des procédés apparentés à cette voie permettant l'identification de composés destinés au traitement de maladies liées à une prolifération cellulaire, une invasion et/ou une métastase telles qu'un cancer. En particulier, la présente invention porte sur l'activité phosphatase de Eya et du complexe Eya-Six en tant que cible pour identifier de nouveaux agents thérapeutiques destinés au traitement de troubles prolifératifs, invasifs et/ou métastasiques, et sur des compositions identifiées à l'aide des procédés décrits ici.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20110312918