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1. (WO2010077682) TREATMENT OF HIV AND AIDS USING PROBIOTIC LACTOBACILLUS REUTERI
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077682 International Application No.: PCT/US2009/067200
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
A61K 35/74 (2006.01) ,A61P 31/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
Applicants:
LEMKE, James, Allen [US/US]; US (AllExceptUS)
Inventors:
LEMKE, James, Allen; US
Agent:
DOCTER, Stephen, H; Reinhart Boerner Van Deuren S.C. 1000 North Water Street, Suite 1700 Milwaukee, Wl 53202, US
Priority Data:
61/120,70808.12.2008US
Title (EN) TREATMENT OF HIV AND AIDS USING PROBIOTIC LACTOBACILLUS REUTERI
(FR) TRAITEMENT DU VIH ET DU SIDA À L'AIDE DE LACTOBACILLUS REUTERI PROBIOTIQUE
Abstract:
(EN) A method for treating or preventing a Human Immunodeficiency Virus (HIV) infection, or treating or preventing Acquired Human Immunodeficiency Syndrome (AIDS), in a subject in need thereof, is disclosed. The method involves colonizing a genetically modified probiotic Lactobacillus reuteri RC-14 in the gastrointestinal tract of a subject, wherein the probiotic is able to secrete two or more fusion inhibitors that decrease or prevent HIV production and CD4+ T cell depletion in the gastrointestinal tract.
(FR) La présente invention porte sur une méthode de traitement ou de prévention d'une infection par le virus de l'immunodéficience humaine (VIH) ou d'une méthode de traitement ou de prévention du syndrome de l'immunodéficience humaine acquise (SIDA), chez un sujet en ayant besoin. La méthode consiste à coloniser Lactobacillus reuteri RC-14 probiotique génétiquement modifié dans le tractus gastro-intestinal d'un sujet, le probiotique étant capable de sécréter deux inhibiteurs de fusion ou plus qui diminuent ou empêchent la production du VIH et l'appauvrissement en lymphocytes T CD4+ dans le tractus gastro-intestinal.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)