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1. (WO2010077680) COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077680 International Application No.: PCT/US2009/067197
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
C07D 487/04 (2006.01) ,C07D 417/12 (2006.01) ,C07D 403/14 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
VM PHARMA LLC [US/US]; 45535 Northport Loop East Fremont, California, US (AllExceptUS)
WU, Jay Jie-Qiang [US/US]; US (UsOnly)
WANG, Ling [CN/US]; US (UsOnly)
Inventors:
WU, Jay Jie-Qiang; US
WANG, Ling; US
Agent:
LU, Yong; Cooley LLP 777 6th Street, NW Suite 1100 Washington, DC 20001, US
Priority Data:
61/120,82708.12.2008US
Title (EN) COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS
(FR) COMPOSITIONS D'INHIBITEURS DE TYROSINE KINASE DE RÉCEPTEUR PROTÉIQUE
Abstract:
(EN) The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF recptor TrkA.
(FR) La présente invention porte sur de nouveaux composés hétérocyliques substitués synthétiques et sur des compositions pharmaceutiques contenant ceux-ci qui sont capables d'inhiber ou d'antagoniser une famille de tyrosine kinases de récepteur, de kinases apparentées à la tropomysosine (Trk), en particulier le récepteur de facteur de croissance neural (NGF), TrkA. L'invention porte en outre sur l'utilisation de tels composés pour le traitement et/ou la prévention de la douleur, d'un cancer, d'une resténose, de l'athérosclérose, du psoriasis, d'une thrombose ou d'une maladie, d'un trouble ou d'une lésion lié à une dysmyélinisation ou démyélinisation ou d'une maladie ou d'un trouble associé à des activités anormales du récepteur TrkA au NGF.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2376495JP2012511054US20110301133CN102292338RU2011128013CA2746220
JP2014218524MX2011006108KR1020110114565RU0002586212BRPI0922224JP2016180005
NZ593937AU2009333537CN106336400AU2016200153AU2017248456JP2018002741
IN5183/DELNP/2011